Genomic mosaicism in two strains of dengue virus type 3 |
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| Affiliation: | Laboratory of Molecular Evolution and Bioinformatics, Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 1734, CEP: 05508-000, São Paulo, SP, Brazil |
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| Abstract: | Recombination is a significant factor driving genomic evolution, but it is not well understood in Dengue virus. We used phylogenetic methods to search for recombination in 636 Dengue virus type 3 (DENV-3) genomes and unveiled complex recombination patterns in two strains, which appear to be the outcome of recombination between genotype II and genotype I parental DENV-3 lineages. Our findings of genomic mosaic structures suggest that strand switching during RNA synthesis may be involved in the generation of genetic diversity in dengue viruses. |
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| Keywords: | Dengue virus type 3 Phylogeny Recombination Split decomposition |
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