Dynamic regulation of innate lymphoid cells in the mucosal immune system |
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| Authors: | Fei Shao Dou Yu Pengyan Xia Shuo Wang |
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| Affiliation: | 1.CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China ;2.University of Chinese Academy of Sciences, Beijing, China ;3.Division of Life Sciences of Medicine, University of Science and Technology of China, Hefei, China ;4.Department of Immunology, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Peking University, Beijing, China |
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| Abstract: | The mucosal immune system is considered a local immune system, a term that implies regional restriction. Mucosal tissues are continually exposed to a wide range of antigens. The regulation of mucosal immune cells is tightly associated with the progression of mucosal diseases. Innate lymphoid cells (ILCs) are abundant in mucosal barriers and serve as first-line defenses against pathogens. The subtype changes and translocation of ILCs are accompanied by the pathologic processes of mucosal diseases. Here, we review the plasticity and circulation of ILCs in the mucosal immune system under physiological and pathological conditions. We also discuss the signaling pathways involved in dynamic ILC changes and the related targets in mucosal diseases. |
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| Keywords: | ILCs transdifferentiation translocation dynamic regulation mucosal immune system |
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