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直接机器参数优化技术在鼻咽癌调强放疗的应用
引用本文:李龙根,徐志勇,胡伟刚. 直接机器参数优化技术在鼻咽癌调强放疗的应用[J]. 中国癌症杂志, 2006, 16(12): 1038-1042
作者姓名:李龙根  徐志勇  胡伟刚
作者单位:复旦大学附属肿瘤医院放疗科,复旦大学上海医学院肿瘤学系,上海,200032
摘    要:背景与目的:调强放射治疗是最先进的放疗技术之,直接机器参数优化技术是调强放疗设计中一种先进的算法。本研究比较鼻咽癌静态调强放射治疗(IMRT)中采用直接机器参数优化(DMPO)技术和传统技术的剂量学差异。方法:选取2005年2月-2006年5月的11例在复旦大学附属肿瘤医院采用IMRT治疗的鼻咽癌患者,根据与原治疗计划相同的布野方式、处方剂量和目标函数,采用直接机器参数优化(DMPO)技术重新设计计划,预先设置不同的最大子野数,分别为100、90、80、70个,对应的计划为DMP0100,DMP090,DMP080DMP070。新计划与原计划(treat)分别对总跳数(MU),总子野数(segments),靶区和正常组织剂量分布及适形数(CI)进行比较。结果:所有计划都满足临床处方剂量要求,从适形指数看,采用DMPO技术的计划(DMP0100,DMP090,DM—P080,DMP070)都高于传统技术计划(treat),在均匀性上,DMP0100,DMP090,DMP080与传统技术计划相似,DM—P070略差;对一些重要器官的保护上,DMP0100,DMP090可达到或优于传统技术计划。采用DMPO技术,总子野数为相当于传统技术的50%时即可达到相同的处方要求,同时在总MU数和照射时间上也有减少。结论:在鼻咽癌调强中,采用DMPO技术优化的计划叮在确保满足靶区和正常组织受量的同时,大大减少总子野数,减少总MU数和治疗时间。

关 键 词:鼻咽癌  调强放疗  直接机器参数优化
文章编号:1007-3639(2006)12-1038-05
收稿时间:2006-08-01
修稿时间:2006-09-19

The application of direct machine parameter optimization technique in the treatment of nasopharyngeal carcinoma
LI Long-gen,XU Zhi-yong,HU Wei-gang. The application of direct machine parameter optimization technique in the treatment of nasopharyngeal carcinoma[J]. China Oncology, 2006, 16(12): 1038-1042
Authors:LI Long-gen  XU Zhi-yong  HU Wei-gang
Abstract:Background and purpose:Indensity modulated radiotherapy(IMRT) is an advanced method in radiotherapy field.Divect machine optimization technique is an good aritmetic for IMRT optimization.The purpose of this study was to compare the dosimetric differences between traditional technique and direct machine parameter optimization(DMPO) technique in the treatment of nasopharyngeal carcinoma(NPC) using step and shoot IMRT.Methods:Eleven patients of(NPC) were treated with step and shoot IMRT in Cancer Hospital,Fudan University from Feb.2005 to May 2006.Their plans(original plan,defined as treat) were archived for comparing with four kinds of IMRT plans(defined as DMPO100,DMPO90,DMPO80,DMPO70) with different predefined maximum number of segments(100,90,80,70,respectively),which were designed to use direct machine parameter optimization(DMPO) technique.We compared the total monitor units(MU),total segments,dose distribution and conformity index among the plans.Results:All the plans showed similar target coverage.Compared with traditional technique,IMRT plans with DMPO technique showed higher conformity index,and had similar uniformity except plan DMPO70.The dose distributions of DMPO100 and DMPO90 were similar or superior to the original plan(treat) in terms of critical organs.Without sacrificing plan quality,the total segments were about half of traditional plan if DMPO technique was used for planning.Moreover,the total monitor units(MUs) and the radiation time were decreased.Conclusions:Compared with traditional technique,plans designed with DMPO technique show sharp decrease in total segments without sacrificing plans quality in the treatment of nasopharyngeal carcinoma(NPC).The DMPO technique can also decrease the total MUs and radiation time.
Keywords:nasopharyngeal carcinoma   intensity modulated radiotherapy   direct machine parameter optimization
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