前列腺增生患者手术前后雄激素改变与术后补充雄激素的研究

目的: 探讨前列腺增生患者手术前后雄激素变化与补充雄激素的对比观察研究。　方法: 64例前列腺增生病例分为Ⅰ、Ⅱ两组 (n1 =25、n2 =39),分别在手术前 1周和手术后 2周采集血清样本,以测定血清中黄体生成素(LH)、卵泡刺激素(FSH)、睾酮(T)、游离睾酮(fT)浓度值;采用经膀胱耻骨上前列腺摘除术,术后Ⅰ组给予补充十一酸睾酮治疗;Ⅱ组作为对照,未予补充。　结果: Ⅰ、Ⅱ两组病例手术前血清LH、FSH、T、fT浓度值比较差异无显著性(P>0. 05),组间具有可比性。两组病例手术前后上述浓度的差值比较差异有极显著性 (P<0. 01)。Ⅰ组病例术后血清LH、FSH、T、fT浓度值的升降幅度明显小于Ⅱ组。　结论: 行前列腺摘除术后,病理证实为良性前列腺增生者,如果有雄激素缺乏症状,则可以适当补充雄性激素,以改善患者的整体状况。

Pre- and Post-prostatectomy Variation and Supplement of Sexual Hormones in Patients with Benign Prostatic Hyperplasia

OBJECTIVE: To explore the variation of sexual hormones (T and fT) before and after prostatectomy and their post-operative supplement in patients with benign prostatic hyperplasia (BPH). METHODS: Sixty-four cases of BPH were randomly divided into a treatment group (Group I, n = 25) and a control group (Group II, n = 39). Plasma LH, FSH, T and fT were measured by radioimmunoassay a week before and two weeks after prostatectomy. After operation, Group I received supplement of testosterone undecanoate, while Group II received none. RESULTS: The variations of plasma LH, FSH, T and fT were not statistically significant in the two groups before prostatectomy (P > 0.05), but obviously less in Group I than in Group II after operation (P < 0.01). CONCLUSION: Testosterone supplement is a useful therapy for post-prostatectomy patients with androgen deficiency.