年龄、性别及2型糖尿病对于胃癌发生的风险：一项单一机构的回顾性分析

糖尿病与多种肿瘤的发生发展有关。然而,与胃癌发生相关的潜在风险因素,包括合并2型糖尿病（T2DM）是否与胃癌发生相关,仍不清楚。本研究搜集了2010年1月~2012年12月我院收治的1320例胃癌患者（胃癌组）和1252个甲状腺结节的患者（对照组）的基本信息,采用病例对照研究方法分析。应用Logistic回归分析评估合并T2DM情况、性别、年龄、身体质量指数（BMI）等对胃癌发生的影响。结果表明,胃癌组中416例T2DM占31.5%,对照组120例T2DM占9.6%,两组间具有极其显著差异（P=0.000）。与对照组相比,Logistic回归分析显示男性患者以及老年人群（年龄大于65岁）有较高发生胃癌的风险。此外,T2DM人群发生胃癌的风险也更高。年龄、T2DM、性别和体重指数的OR值分别为16.951,15.130,2.658和0.224。本研究表明年龄、性别和2型糖尿病是胃癌发生的危险因素之一,即患有2型糖尿病且年龄在65岁以上的男性患者是胃癌的高发人群,在这三个危险因素中,患有2型糖尿病的风险值仅次于年龄,也有可能是这些因素之间的共同作用导致胃癌的发生。

Age,gender and type 2 diabetes contribute to the risk of gastric cancer: a retrospective single institution analysis

Diabetes is involved in the development of several cancers. However, whether type 2 diabetes mellitus （T2DM） as well as other potential risk factors are related to gastric cancer （GC） remains unclear. In this study, 1320 patients with gastric cancer （gastric cancer group） and 1252 thyroid nodule patients （control group）, who were admitted in our hospital from Jan 2010 to Dec 2012, were analyzed in a case-control study. Logistic regression analysis was applied to evaluate the risk of diabetes condition, gender, age, body-mass index （BMI） level and other factors for GC. There were 416 patients with DM in the gastric cancer group （31.5%） and 120 patients with DM in the control group （9.6%）. The differences between the two groups were significant （P = 0.000）. Compared with the control group, the logistic regression analyses suggested that male patients had a higher risk of GC. Moreover, older individuals （especially over 65 years） were more susceptible to GC, and as for T2DM, it was found to be associated with GC, that is, the incidence in the gastric cancer group was significantly higher than in the control group. The OR values of age, T2DM, gender and BMI were 16.951, 15.130, 2.658 and 0.224, respectively. In conclusion, age, gender and T2DM are the risk factors of gastric cancer. Furthermore, male patient over 65 years with T2DM is susceptible to GC, and T2DM is the risk factor only second to age, and there might be synergistic effects among these factors.