硝酸银使临床分离多重耐药革兰氏阳性菌和革兰氏阴性菌重新对阿米卡星敏感（英文）

高浓度的硝酸银可抑制所有检测的临床分离耐多重药菌株（最小抑菌浓度为32–64μM）。本研究报道了阿米卡星与亚致死量（15μM）的硝酸银在体外联用对临床分离多重耐药菌的作用。硝酸银可使原本已对阿米卡星耐药的泛耐药鲍曼不动杆菌和耐甲氧西林金黄色葡萄球菌重新变敏感（将原本都大于128μg/mL的最小抑菌浓度分别降低至2–16μg/mL和32μg/mL）。硝酸银同样可以将阿米卡星对能够产生超广谱β内酰胺酶的绿脓杆菌和大肠杆菌的最小抑菌浓度分别由16–32μg/mL和16μg/mL降至〈1–4μg/mL和〈1μg/mL。

Silver nitrate restores susceptibility of clinical multidrug resistant gram-negative and gram-positive bacteria to amikacin in vitro

Silver nitrate could inhibit the clinical multidrug resistant isolates at high concentrations（with minimal inhibitory concentrations（MICs） from 32 μM to 64 μM）. The activities of amikacin in the presence of sub-lethal silver nitrate（15 μM） were tested for the combinational effects against multidrug resistant clinical isolates in vitro. Silver nitrate restored the susceptibility of drug-resistant Acinetobacter baumannii and methicillin-resistant Staphylococcus aureus to amikacin. It lowered the MICs of amikacin from 〉128 μg/mL to（2–16） μg/mL and 32 μg/mL, respectively, and lowered the MICs of amikacin on extended spectrum β-lactamase-producing Pseudomonas aeruginosa and Escherichia coli from（16–32） μg/mL and 16 μg/mL to（〈1–4） μg/mL and 〈1 μg/mL, respectively.