亚低温治疗急性重型颅脑损伤28例疗效观察

目的观察早期使用亚低温疗法对急性重型颅脑损伤的疗效。方法56例成人急性重型颅脑损伤随机分成二组。对照组使用常规疗法;治疗组使用常规治疗方法加亚低温治疗。观察每位患者的生命体征、颅内压、头颅CT扫描结果、恢复情况、病死率。结果治疗组患者生命体征的改变、颅内压的改变、脑水肿的CT改变、病死率变化均低于对照组。治疗组：恢复苏醒者21例,占75%,植物状态者3例,占10.8%,死亡4例,占14.2%;对照组：恢复苏醒者13例,占46.4%,植物状态者5例,占17.9%,死亡10例,占35.7%。结论亚低温疗法能提高重度颅脑外伤患者的康复率,降低其伤残率及病死率。

STUDY OF CLINICAL EFFECTS OF MILD HYPOTHERMIA ON 28 PATIENTS WITH SEVERE ACUTE BRAIN INJURY

Objective To study the effect of mild hypothermia on 56 patients with severe brain injury.Methods All 56 patients with severe brain injury were randomly divided into hypothermic therapy group（28 cases） and control group（28 cases）.Mild hypothermia therapy was given immediately after admission or emergency surgery to keep the rectal temperature at 33～35℃ for one to seven days.Meanwhile,the vital signs,blood lactic acid content,and CT were measured.The prognosis was assessed by Glasgow Outcome Scale（GOS）.Results In comparison with control group,the vital signs and blood lactic acid content were significantly decreased respectively in hypothermic group （P〈0.05）. But the prognosis of patients in hypothermic group improved obviously. The decreased mortality and good recovery were also found in hypothermia group. Conclusion Mild hypothermia therapy is safe and effective for preventing brain damage in patients with severe brain injury.