乙型肝炎多重感染临床特征研究

目的 :分析乙型肝炎多重感染的病原学类型及其临床特征。方法 :乙型肝炎多重感染患者 94例 ,其中三重感染 80例 ,四重感染 14例 ,用日期随机法抽取同期单纯乙型肝炎 10 0例作为对照组进行分析。结果 :乙型肝炎多重感染以丁肝病毒 (HDV)、巨细胞病毒 (CMV)与甲肝病毒 (HAV)者居多 ,分别为 79.8%、5 1.1%、40 .4% ,17例急性肝炎患者中有 16例合并HAV感染。乙型肝炎多重感染组中急性肝炎、慢性重型肝炎与慢性肝炎 (重度 )的比例明显高于单纯感染组 ,而慢性肝炎 (轻度 )与肝硬化明显低于单纯感染组 (P <0 .0 0 1)。结论 :与单纯感染相比 ,乙型肝炎多重感染肝功能损害严重 ,有重症化倾向 ,易急性发作

MULTIPLE VIRUS INFECTIONS IN PATIENTS WITH HEPATITIS B:CLINICAL PROFLLES

Objective:To analyse the virological categories of multiple virus infection in patients with hepatitis B and to evaluate its clinical significance.Methods:The virological and clinical features in 94 patients with hepatitis B accompanied by multiple viruses, which included 80 cases with three types of viruses and 14 with four types of viruses, were analysed and compared with those in 100 patients only with hepatitis B.Results:The percents of patients with hepatitis D virus (HDV), cytomegalovirus (CMV) and hepatitis A virus (HAV) infections in 94 patients was 79.8%, 51.1%, 40.4%, respectively. Sixteen out of 17 acute hepatitis patients were infected with HAV. The cases with acute hepatitis, chronic serious hepatitis and chronic hepatitis (severe) in multiple virus group were more significant than those in single virus group, but the number of patients with chronic hepatitis (mild) or cirrhosis in the former group was less than that in the latter group (all P<0.001). The liver function injury was more severe in the patients with multiple virus infections, which was accompanied by longer period of hospitalization.Conclusions:The patient with multiple virus infections has more severe liver function injury and more opportunity to get acute attack compared with the single virus infection patient.