1332例已婚育龄妇女致畸病毒免疫状况研究

目的:了解未经接种致畸病毒(TORCH)疫苗的育龄妇女其免疫球蛋白TORCH-IgG水平。方法:应用酶联免疫法对1 332例19~44岁无TORCH疫苗接种史及在广东地区居住5年以上的孕前妇女血清风疹病毒(RUV)IgG、巨细胞病毒(CMV)IgG、弓形虫(TOX)IgG、单纯疱疹Ⅱ病毒(HSVⅡ)IgG及B19微小病毒(B19)IgG检测,并按年龄分组统计阳性率。结果:总体风疹病毒IgG阳性率86.6%、巨细胞病毒IgG阳性率93.2%、弓形虫IgG阳性率25.5%、单纯疱疹Ⅱ病毒IgG阳性率85.3%及B19微小病毒IgG阳性率38.1%,各指标阳性率似随年龄增加而升高,但各年龄组间无显著差异。结论:TORCH-IgG阳性(未经接种疫苗)代表本地的自然感染过程,育龄妇女各年龄组TORCH-IgG阳性率无显著差异,即任一年龄妊娠,其孕期感染TORCH几率及其胎儿获得宫内垂直感染几率相同。

Prevalence of TORCH - IgG antibodies in non - vaccination of married fertile aged women in Guangzhou

Objective:To investigate the status of TORCH-IgG antibodies in non-immunized of married fertile-aged women in Guangzhou.Methods:Enzyme-linked immunosorbent assay(ELISA) was used to detect TORCH(Rubella virus,Cytomegalo virus,Herpes simplex-Ⅱ,Parvoirus B19,Toxoplasma)-specific immunoglobulin G(IgG) in 1 332 non-immunized and married fertile-aged women(age 19~44 years),All those women have lived in Guangdong at least 5 years.The positive rates are analyzed according to the women age group.Results:The positive rate of overall serum: RUV 1153/1332,CMV 1242/1332,HSVⅡ 1137/1332,B19 508/1332,TOX 339/1332,The rate increase by age,but no significant differences in each group of women's age from 19-44years(P>0.05).Conclusion:This study shows that susceptibility of TORCH is in the same in married fertile-aged women(age 19~44years) as in their pregnancy.