c-erbB-2、MMP-2、MMP-9表达水平与乳腺癌恶性程度的相关性

目的探讨c—erbB-2、基质金属蛋白酶（matrix metalloproteinase，MMP）-2、MMP-9表达水平与乳腺癌恶性程度间的相关性。方法采用免疫组化染色法测定乳腺癌患者c-erbB-2、MMP-2、MMP-9的表达水平，结合临床资料进行相关性分析研究。结果MMP-2、MMP-9的表达水平与乳腺癌临床分期之间存在一定的相关性（P〈0．05），其中MMP-2的表达水平与乳腺癌的局部侵袭存在显著的相关性（P〈0．01），MMP-9的表达水平与乳腺癌的淋巴结转移存在显著的相关性（P〈0．01）；c—erbB-2的表达水平与乳腺癌组织的雌、孕激素受体表达水平之间存在显著的相关性（P〈0．01）。结论MMP-2、MMP-9与乳腺癌的局部侵袭和远处转移的发生、发展关系密切，既可以用于评价乳腺癌的恶性程度又可以用作乳腺癌治疗的靶点。

Correlation between the Expression of c-erbB-2, MMP-2,MMP-9 and Malignant Degree of Mammary Cancer

Objective To study the correlation between the expression of c-erbB-2, matrix metalloproteinase (MMP)-2, MMP-9 and malignant degree of mammary cancer.Methods The expression of c-erbB-2, MMP-2 and MMP-9 was detected by using immunohistochemical staining, and their correlation with clinical data was analyzed.Results The expression of MMP-2 and MMP-9 had a correlation with clinical stage of mammary cancer (P<0.05). The expression of MMP-2 had a remarkable correlation with local invasion of mammary cancer (P<0.01). The expression of MMP-9 had a remarkable correlation with lymph node metastasis of mammary cancer (P<0.01). c-erbB-2 had a correlation with the expression of ER and PR of mammary cancer (P<0.01).Conclusion MMP-2 and MMP-9 are closely correlated with the local invasion and distant metastasis of mammary cancer. They can be taken as the assessing marker about staging of mammary cancer and target of therapy.