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| 射频消融后残余肿瘤模型的制作及病理观察 | |
| 引用本文： | 何东风,徐克,蒋宝国,王悦,邵海波,曹智刚,戴旭,郭敏,姜惠杰,刘瑞宝. 射频消融后残余肿瘤模型的制作及病理观察[J]. 中国医学影像技术, 2009, 25(10): 1753-1756 |
| 作者姓名： | 何东风 徐克 蒋宝国 王悦 邵海波 曹智刚 戴旭 郭敏 姜惠杰 刘瑞宝 |
| 作者单位： | 1. 哈尔滨医科大学附属肿瘤医院介入科,黑龙江,哈尔滨,150081 2. 中国医科大学附属第一医院放射科,辽宁,沈阳,110001 3. 中国医科大学附属第四医院放射科,辽宁,沈阳,110032 4. 秦皇岛市第一医院放射科,河北,秦皇岛,066000 5. 哈尔滨医科大学附属第二医院放射科,黑龙江,哈尔滨,150086 |
| 基金项目： | 黑龙江省科技厅青年基金，黑龙江省教育厅科学技术研究(面上)项目计划 |
| 摘 要： | 目的 观察兔VX2射频消融后残余肿瘤模型不同时间段病理形态学变化.方法 超声引导经皮穿刺48只新西兰白兔接种VX2肿瘤,并开腹射频消融制作残余肿瘤模型.将模型随机分成6组,每组8只,分别于射频消融术(RFA)之前、术后1天、3天、1周、2周及3周观察病理学变化.结果 残余肿瘤组织射频消融术后MVD、VEGF及PCNA表达即明显减低,一直维持较低水平至射频消融后2周;RFA后2周至第3周,MVD、VEGF及PCNA表达再次增加.结论 射频消融治疗后残余肿瘤短期内受到抑制,仍需要进一步治疗. |
| 关 键 词： | 导管消融 模型 动物 残余肿瘤 |
| 收稿时间： | 2009-01-15 |
| 修稿时间： | 2009-07-22 |
Establishment and pathological observation of rabbit remnant carcinoma models after RFA therapy |
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| HE Dong-feng,XU Ke,JIANG Bao-guo,WANG Yue,SHAO Hai-bo,CAO Zhi-gang,DAI Xu,GUO Min,JIANG Hui-jie and LIU Rui-bao. Establishment and pathological observation of rabbit remnant carcinoma models after RFA therapy[J]. Chinese Journal of Medical Imaging Technology, 2009, 25(10): 1753-1756 | |
| Authors: | HE Dong-feng XU Ke JIANG Bao-guo WANG Yue SHAO Hai-bo CAO Zhi-gang DAI Xu GUO Min JIANG Hui-jie LIU Rui-bao |
| Affiliation: | Department of Interventional Radiology, The Tumor Hospital of Harbin Medical University, Harbin 150081, China;Department of Radiology, the First Affiliated Hospital of China Medical University, Shenyang 110001, China;Department of Radiology, the Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China;Department of Radiology, the First Hospital of Qinhuangdao City, Qinhuangdao 066000, China;Department of Radiology, the First Affiliated Hospital of China Medical University, Shenyang 110001, China;Department of Radiology, the Second Affiliated Hospital of Harbin Medical University, Haerbin 150086, China;Department of Radiology, the First Affiliated Hospital of China Medical University, Shenyang 110001, China;Department of Radiology, the First Affiliated Hospital of China Medical University, Shenyang 110001, China;Department of Radiology, the Second Affiliated Hospital of Harbin Medical University, Haerbin 150086, China;Department of Interventional Radiology, The Tumor Hospital of Harbin Medical University, Harbin 150081, China |
| Abstract: | Objective To establish rabbit model of remnant carcinoma after RFA therapy, and to observe pathomorphological changes of remnant carcinoma in different time. Methods Forty-eight New Zealand white rabbits underwent ultrasound-guided percutaneous inoculation with VX2 carcinoma, then RFA therapy was performed to made models of remnant carcinoma. These models were averagely divided into 6 groups randomly (each n=8). Rabbits in each group was killed and pathologically observed before RFA and 1 d, 3 d, 1 week, 2 and 3 weeks after operation, respectively. Results The expression of MVD,VEGF and PCNA in remnant VX2 carcinomas tissues decreased significantly, but increased 2-3 weeks after RFA. The remnant VX2 carcinomas tissues were in inhibitory state 2 weeks after RFA. Conclusion The growth of remnant carcinoma could be inhibited in short term after RFA. Further therapy is necessary. |
| Keywords: | Catheter ablation Models, animal Remnant carcinoma |
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