| 低剂量丝裂霉素C辐射防护作用的初步研究 |
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| 引用本文： | 高峰,孙晓玲,王彬,梁硕,张海英. 低剂量丝裂霉素C辐射防护作用的初步研究[J]. 中国实验诊断学, 2006, 10(12): 1475-1476 |
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| 作者姓名： | 高峰 孙晓玲 王彬 梁硕 张海英 |
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| 作者单位： | 1. 吉林省疾病预防控制中心,吉林,长春,130062
2. 吉林大学公共卫生学院,吉林,长春,130021 |
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| 摘 要： | 目的 观察丝裂霉素C（MMC）对辐射损伤小鼠染色体畸变的影响。方法 小鼠腹腔注射低剂量MMC，再给大剂量X射线照射，或先给大剂量X射线照射再给低剂量MMC。观察小鼠骨髓细胞染色体畸变。结果 所有低剂量MMC处理组小鼠骨髓细胞染色体畸变率均低于单纯大剂量照射组。结论 低剂量MMC可以减轻辐射所致的染色体损伤，具有辐射防护作用。
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| 关 键 词： | 丝裂霉素C 染色体畸变 辐射防护 |
| 文章编号： | 1007-4287(2006)12-1475-02 |
| 收稿时间： | 2005-04-01 |
| 修稿时间： | 2005-04-01 |
Effect of Low Dose Mitomycin C on radio protective Function |
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| GAO Feng,SUN Xiao-ling,WANG Bin,LIANG Shuo,ZHANG Hai-ying. Effect of Low Dose Mitomycin C on radio protective Function[J]. Chinese Journal of Laboratory Diagnosis, 2006, 10(12): 1475-1476 |
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| Authors: | GAO Feng SUN Xiao-ling WANG Bin LIANG Shuo ZHANG Hai-ying |
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| Affiliation: | 1. Department of Toxicological Laboratory, Hygiene Monitoring Test Center, Jilin Changchun 130062, China;2. School of Public Health, Jilin University , Jilin Changchun 130021, China |
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| Abstract: | Objective To study effect of low dose Mitomycin C(MMC) on chromosome aberration of bone marrow cells of mice treated by 2.0Gy X ray.Methods The mice were treated by low dose MMC before or after treated by high dose X-ray.And chromosome aberration of bone marrow cells of mice was observed.Results The chromosome aberration in all the group of treated by low dose MMC was lower than that in the 2Gy X-ray group.Conclusion Low dose MMC has a better radiation prevention effect. |
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| Keywords: | mitomycin chromosome aberration radio protection |
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