Selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain by infusion of a stable substance P analogue into the ventral tegmental area |
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| Authors: | Peter J.Elliott Jonathan E. Alpert Michael J. Bannon Susan D. Iversen |
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| Affiliation: | 1. Psychological Neuroscience Laboratory (PNL), Psychology Research Center (CIPsi), School of Psychology, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal;2. Department of Experimental Psychology, Complutense University of Madrid (UCM), 28223 Madrid, Spain;1. Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA;2. German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany;3. Chair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-University, Munich, Germany;4. Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany |
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| Abstract: | Microinfusion of the metabolically stable substance P (SP) agonist, [pGlu5,MePhe8,Sar9]-SP5-11 (DiMe-C7), into the ventral tegmental area (VTA) of rat brain increased levels of the dopamine (DA) metabolite dihydroxyphenylacetic acid in the prefrontal cortex (+ 120%) and nucleus accumbens (+30%) but not in other regions of forebrain. In contrast, infusions of DiMe-C7 or SP into the lateral ventricles or microinfusions of SP into VTA failed to elicit increases in DOPAC levels in forebrain. DA levels were unaffected by SP or DiMe-C7 regardless of the route of administration. These data and previous studies suggest a role for endogenous SP in the modulation of mesocortical and mesolimbic DA neurones. |
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| Keywords: | [pGlu5, MePhe8, Sar9]-SP5– 11 (DiMe-C7) substance P dopamine neuron ventral tegmental area footshock stress dopamine metabolite prefrontal cortex nucleus accumbens |
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