新辅助化疗治疗宫颈癌对细胞增殖与凋亡的影响分析

目的探讨新辅助化疗治疗宫颈癌对细胞增殖与凋亡的影响,从而了解新辅助动脉化疗的作用机制,为宫颈癌的治疗提供参考。方法 52例Ib-IIb期宫颈癌患者平分两组,观察组施行动脉灌注栓塞化疗后手术,对照组直接手术治疗,观察临床疗效。分别记录两组手术病例的术中出血量,并作比较;同时检测动脉灌注栓塞化疗前、后及直接手术患者的肿瘤细胞增殖指数（Ki-67）及凋亡指数（AI）。结果观察组宫颈癌动脉灌注栓塞化疗总有效率为80.8%,对照组术后须行放疗或化疗者20例,占76.9%。观察组手术病例手术出血量为（362.5±11.5）ml,对照组手术出血量为（524.5±15.0）ml,两组比较差异有统计学意义（P〈0.05）。观察组动脉化疗前活检标本,Ki-67指数（%）为（67.5±76）,对照组直接手术病理标本,Ki-67指数（%）为（80.1±8.5）。观察组AI（%）为（3.5±1.3）,对照组检测AI（%）为（0.8±0.3）。结论 Ib-IIb期宫颈癌行新辅助动脉灌注栓塞化疗,可显著缩小病灶体积,从而提高患者生活质量。可明显减少手术中出血量,有利于患者康复。同时促进肿瘤细胞增殖显著下降、凋亡显著增加,提示动脉化疗有抑制肿瘤细胞增殖、促进凋亡的作用。

Effects Analysis of Neoadjuvant Chemotherapy in Treatment of Cervical Cancer Cell Proliferation and Apoptosis

Objective To discuss the effects of neoadjuvant chemotherapy in treatment of cervical cancer cell proliferation and apoptosis for understanding the role of neoadjuvant intraarterial chemotherapy mechanism and provide a reference for the treatment of cervical cancer. Methods Totally 52 cases of Ib-IIb cervical cancer patients were divided into two groups,the observation group were impleted the arterial chemoembolization after operation,the control group were directly treated by the surgical treatment,the clinical efficacy was observed.And the haemorrhage volume during opertation of the two groups were recorded;Simultaneously detected the tumor cell proliferation index（Ki-67） and apoptosis index（AI） of arterial embolization chemotherapy before and directly after surgery in patients. Results The total effective rate of the observation group was 80.8%,and 20 cases were treated by the radiotherapy or chemotherapy after surgery in the control group.The observation group of the patients with haemorrhage volume was（362.5±11.5）ml,so that was（524.5±15.0）ml in the control group（P0.05）.The Ki-67 index（%） was（67.5±76） of artery biopsy specimens before chemotherapy in the observation group,so that was（80.1±8.5） in the control group.The AI（%） was（3.5±1.3） in the observation group,so that was（0.8±0.3） in the control group. Conclusion Neoadjuvant chemotherapy in treatment of cervical cancer can significantly reduce the tumor volume,enhance the quality of life.So it can significantly reduce the amount of bleeding,it is good for patients to rehabilitation.Also it can promote tumor cell proliferation and apoptosis,this suggests that arterial chemotherapy can inhibit tumor cell proliferation and apoptosis.