Photodynamic therapy in dermatology beyond non-melanoma cancer: An update |
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| Affiliation: | 1. Department of Dermatology, West China Hospital of Sichuan University, Chengdu, Sichuan,610041,China;2. Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA;3. Department of Dermatology, Harvard Medical School, Boston, MA 02115, USA;4. Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA;1. 1st Department of Dermatology, University Clinic, “Andreas Sygros” Hospital, Athens, Greece;2. Department of Dermatology, Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts;3. Tufts University School of Medicine, Boston, Massachusetts;4. Melanoma Genetics Program/MGH Cancer Center, Massachusetts General Hospital, Boston, Massachusetts;1. Department of Dermatology, Maastricht University Medical Center, Maastricht, The Netherlands;2. Department of Epidemiology, Maastricht University, Maastricht, The Netherlands;3. GROW School for Developmental Biology and Oncology, Maastricht University, Maastricht, The Netherlands;4. Faculty of Health, Medicine, and Life Sciences, Maastricht University, Maastricht, The Netherlands;5. Department of Dermatology, Catharina Hospital, Eindhoven, The Netherlands;1. Instituto de Biologia, Departamento de Biologia Vegetal, Universidade Estadual de Campinas (UNICAMP), 13083-970 Campinas, SP, Brazil;2. Sorbonne Universités, UPMC Univ Paris 06, Centre National de la Recherche Scientifique (CNRS), Laboratoire Jean Perrin (UMR 8237), 4 place Jussieu, 75252 Paris cedex 05, France;1. Department of Surgery, Beckman Laser Institute and Medical Clinic, University of California–Irvine, Irvine, California;2. Department of Biomedical Engineering, University of California–Irvine, Irvine, California;3. Department of Dermatology, Brigham and Women''s Hospital, Harvard Institute of Medicine, Boston, Massachusetts;4. Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi''an, Shaanxi, China;5. Shandong Provincial Institute of Dermatology and Venereology, Jinan, Shandong, China |
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| Abstract: | Photodynamic therapy (PDT) employs a photosensitizer (PS) and visible light in the presence of oxygen, leading to production of cytotoxic reactive oxygen species, which can damage the cellular organelles and cause cell death. In dermatology, PDT has usually taken the form of topical application of a precursor in the heme biosynthesis pathway, called 5-aminolevulinic acid (or its methyl ester), so that an active PS, protoporphyrin IX accumulates in the skin. As PDT enhances dermal remodeling and resolves chronic inflamation, it has been used to treat cutaneous disorders include actinic keratoses, acne, viral warts, skin rejuvenation, psoriasis, localized scleroderma, some non-melanoma skin cancers and port-wine stains. Efforts are still needed to mitigate the side effects (principally pain) and improve the overall procedure. |
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| Keywords: | Photodynamic therapy Cosmetic Dermatology |
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