QT interval variability index and QT interval duration during different sleep stages in patients with obstructive sleep apnea |
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| Institution: | 1. Laboratory of Cardiac Physiology, Institute of Physiology, Komi Science Center, Ural Branch, Russian Academy of Sciences, 50, Pervomayskaya st., Syktyvkar 167982, Russia;2. Department of Physiology, Medical Institute of Pitirim Sorokin Syktyvkar State University, 11, Babushkin st., Syktyvkar 167000, Russia;1. Center of Excellence for the Treatment of Chagas Disease, Olive View-UCLA Medical Center, Sylmar, CA;2. UCLA Cardiac Arrhythmia Center, Ronald Reagan UCLA Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA;1. Department of Epileptology, University of Bonn, Sigmund-Freud-Straße 25, 53127 Bonn, Germany;2. Department of Neuropathology, University of Bonn, Sigmund-Freud-Straße 25, 53127 Bonn, Germany;3. Department of Nuclear Medicine, University of Bonn, Sigmund-Freud-Straße 25, 53127 Bonn, Germany |
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| Abstract: | ObjectivesThe aim of the study was to investigate the impact of obstructive sleep apnea (OSA) on the QT interval variability and duration in patients during different sleep stages.MethodsPolysomnographic recordings of 28 (13 male, 15 female) patients with OSA and 30 (15 male, 15 female) patients without OSA were analyzed. The QT interval variability index (QTVI) and the corrected QT interval (QTc) analyses were performed using two awake, 3–4 non-rapid eye movement (NREM) and three rapid eye movement (REM) sleep episodes (each 300 s). The Bazett formula, linear, and parabolic heart rate correction formulas with two separate α values were used.ResultsQTVI was statistically higher in OSA than in non-OSA patients for males while awake (awake ?0.7 ± 0.3 vs ?1.2 ± 0.2, p = 0.001; NREM ?0.9 ± 0.4 vs ?1.1 ± 0.3, p = 0.110; REM ?1.1 ± 0.3 vs ?1.3 ± 0.2, p = 0.667) and for females in all wake–sleep stages (awake ?0.3 ± 0.7 vs ?0.9 ± 0.5, p = 0.001; NREM ?0.3 ± 0.5 vs ?0.8 ± 0.4, p = 0.002; REM ?0.3 ± 0.5 vs ?1.0 ± 0.4, p < 0.001). QTVI was significantly higher during awake compared to sleep stages in OSA males (p < 0.05); no difference between wake–sleep stages was found in females (p > 0.05). Significant gender differences in QTVI existed in OSA patients during sleep (p < 0.05) but not while awake. No significant differences in QTc between patients groups were observed.ConclusionsOSA is associated with increased QT variability. REM sleep per se does not increase QTVI. In OSA patients, QTVI might be a more useful measure to detect ventricular repolarization abnormality than measures of QTc. |
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| Keywords: | Obstructive sleep apnea QT interval variability QT interval variability index Heart rate-corrected QT interval |
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