Adherence to antiepileptic drugs in children and adolescents: A retrospective study in primary care settings in Germany |
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| Affiliation: | 1. Faculty of Medicine, University of Paris 5, Paris, France;2. Department of Neurology, Epilepsy Center, University of Erlangen, Germany;3. Epidemiology, QuintilesIMS, Frankfurt, Germany;1. Department of Neurosciences, Medical University of South Carolina, 96 Jonathan Lucas St, MSC 616/CSB 301, Charleston, SC 29425-6160, USA;2. University of Rochester Medicine, Golisano Children''s Hospital, 601 Elmwood Avenue, Box 777R, Rochester, NY 14642, USA;3. Department of Public Health Sciences, Medical University of South Carolina, 135 Cannon St, Suite 303, MSC 835, Charleston, SC 29425-8350, USA;4. Department of Healthcare Leadership and Management, Medical University of South Carolina, 151-B Rutledge Ave, Building B, MSC 962, Charleston, SC 29425-9620, USA;1. Istanbul University Florence Nightingale Faculty of Nursing, Istanbul, Turkey;2. Istanbul University Istanbul Faculty of Medicine Department of Neurology, Istanbul, Turkey;1. Pediatric Intensive Care Unit, Linkou Chang-Gung Memorial Hospital, Taiwan, ROC;2. School of Nursing, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan, ROC;3. Division of Pediatric Neurology, Department of Pediatrics, Chang-Gung Children’s Hospital and Chang-Gung Memorial Hospital, Taoyuan, Taiwan, ROC;4. Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, NM, USA;1. Columbia University, USA;2. PatientsLikeMe.com, USA;1. All India Institute of Medical Sciences, Delhi, India;2. Department of Neurology, All India Institute of Medical Sciences, Delhi, India;1. Department of Rehabilitation Sciences, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong;2. School of Life Sciences, Faculty of Science, University of Technology Sydney, NSW 2007, Australia;3. Social Determinants of Health Research Center, Qazvin University of Medical Sciences, Shahid Bahounar BLV, Qazvin 3419759811, Iran |
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| Abstract: | ObjectiveThe goal of this study was to analyze adherence to antiepileptic drugs (AED) in children and adolescents treated in pediatric practices in Germany.MethodsThe present study included patients aged between 2 and 17 years who were diagnosed with epilepsy (ICD-10: G40) and had received at least two prescriptions of AED between January 2006 and December 2015 in 243 pediatric practices in Germany. The medication possession ratio (MPR) was used to estimate adherence, and patients with a MPR greater than 80% were considered adherent. The impact of patient and drug characteristics on adherence was analyzed using a multivariate logistic regression model.ResultsA total of 5214 patients were included. Mean age was 10.9 years (SD = 4.9 years). The overall MPR was 88.8% (SD = 34.1%), and 68.9% of patients were considered adherent. Children aged 5 years or younger were more adherent to AED than those aged between 14 and 17 years (OR = 1.22, 95% CI: 1.07–1.39). Individuals living in western Germany were also found to be more adherent than those living in eastern Germany (OR = 1.71, 95% CI: 1.55–1.88). Asthma as a comorbidity (OR = 1.59, 95% CI: 1.29–1.96) was positively and attention-deficit hyperactivity disorder (OR = 0.81, 95% CI: 0.71–0.93) negatively associated with treatment adherence. Finally, no significant association was found between adherence and the type of AED.ConclusionsTwo-thirds of children and adolescents suffering from epilepsy in Germany were adherent to AED. Age, place of residence, and comorbidities were significantly associated with adherence. |
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