Bacterial and viral pneumonia: New insights from the Drakenstein Child Health Study |
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| Affiliation: | 1. Kilimanjaro Christian Medical University College (KCMUCo), Box 2240, Moshi, Tanzania;2. Kilimanjaro Clinical Research Institute (KCRI), Box 2236, Moshi, Tanzania;3. Section Pediatric Infectious Diseases, Laboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands;4. Department of Medical Microbiology, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands |
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| Abstract: | Pneumonia remains the major cause of childhood morbidity and mortality globally, despite improved preventative strategies. Increasing evidence also links early life pneumonia with the development of chronic non-communicable respiratory diseases into childhood and adulthood. The Drakenstein Child Health Study is a unique, multidisciplinary, South African birth cohort, investigating the incidence, risk factors, aetiology and long term impact of early life pneumonia on child health. The study provides novel data showing a high incidence of pneumonia despite excellent immunisation coverage; that pneumonia is due to multiple pathogens; that dysbiosis of the nasopharyngeal flora precedes and predisposes to pneumonia; and that early life pneumonia results in reduced lung function. |
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| Keywords: | Pneumonia Lower respiratory tract infection Aetiology Chronic lung disease Lung function |
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