Outcome of childhood-onset epilepsy from adolescence to adulthood: Transition issues |
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| Affiliation: | 1. Reference Centre for Rare Epilepsies, Pediatric Neurology, Necker-Enfants Malades University Hospital, APHP, University of Paris Descartes, Inserm U1129, Paris, France;2. Department of Medicine, University of Toronto Adult Epilepsy Genetics Program, University of Toronto, Toronto Western Hospital, Toronto, Canada;3. Embryology and Genetics of Congenital Malformations & Pediatric Neurology, Necker Enfants Malades University Hospital, Paris France;4. UCL Institute of Child Health, London, UK;5. Department of Pediatric Neuroscience, Foundation I.R.C.C.S. Neurological Institute C. Besta, Milan, Italy;6. Service de Neurologie, Hôpital de Hautepierre, Strasbourg, France;7. GH Pitie-Salpêtrière-Charles Foix, Epilepsy Unit and Department of Clinical Neurophysiology, Institut du Cerveau et de la Moelle, Paris, France;8. Department of Neurology, Boston Children''s Hospital, Harvard Medical School, Boston, MA, United States;9. Epilepsy Research Group, Free University of Berlin, Berlin, Germany;10. Director, Pediatric Epilepsy Program and Herscot Center for TSC, Massachusetts General Hospital, Boston, MA, United States;11. Dalhousie University, IWK Health Centre, Halifax, Nova Scotia, Canada;1. Psychological Services, Alder Hey Children''s Hospital, Liverpool, United Kingdom;2. The Walton Centre, Liverpool, United Kingdom;1. College of Nursing, Medical University of South Carolina, United States;2. Comprehensive Epilepsy Program, Medical University of South Carolina, United States;3. Department of Pediatrics, Medical University of South Carolina, United States;4. Department of Public Health Sciences, Medical University of South Carolina, United States;5. Department of Neurosurgery, Medical University of South Carolina, United States;6. Department of Neurosciences, Medical University of South Carolina, United States;1. Minnesota Epilepsy Group, P.A., 225 Smith Avenue North, Suite 201, St. Paul, MN 55102, United States;2. Minnesota School of Professional Psychology at Argosy University, 1515 Central Parkway, Eagan, MN 55121, United States;1. University of Colorado College of Nursing, Anschutz Medical Campus, Aurora, CO;2. Department of Family Services, Children''s Hospital Colorado, Aurora, CO;3. Neurology Clinic, Children''s Hospital Colorado, Aurora, CO;4. Division of Child Neurology, University of Colorado School of Medicine, Anschutz Medical Campus, Children''s Hospital Colorado, Aurora, CO |
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| Abstract: | This is the second of three papers that summarize the second symposium on Transition in Epilepsies held in Paris in June 2016. This paper addresses the outcome for some particularly challenging childhood-onset epileptic disorders with the goal of recommending the best approach to transition. We have grouped these disorders in five categories with a few examples for each. The first group includes disorders presenting in childhood that may have late- or adult-onset epilepsy (metabolic and mitochondrial disorders). The second group includes disorders with changing problems in adulthood (tuberous sclerosis complex, Rett syndrome, Dravet syndrome, and autism). A third group includes epilepsies that change with age (Childhood Absence Epilepsy, Juvenile Myoclonic Epilepsy, West Syndrome, and Lennox-Gastaut syndrome). A fourth group consists of epilepsies that vary in symptoms and severity depending on the age of onset (autoimmune encephalitis, Rasmussen's syndrome). A fifth group has epilepsy from structural causes that are less likely to evolve in adulthood. Finally we have included a discussion about the risk of later adulthood cerebrovascular disease and dementia following childhood-onset epilepsy. A detailed knowledge of each of these disorders should assist the process of transition to be certain that attention is paid to the most important age-related symptoms and concerns. |
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