Achievements,challenges, and future perspectives of epidemiologic research in restless legs syndrome (RLS) |
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| Affiliation: | 1. University of Illinois College of Medicine at Urbana-Champaign and Carle Foundation Hospital, Urbana, IL, USA;2. Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA;3. Department of Somnology, Institute of Neuropsychiatry, Tokyo Medical University and Japan Somnology Center, Japan;4. Institute of Epidemiology and Social Medicine, University of Muenster, Germany;1. Sleep Research Center, I.R.C.C.S. “Oasi Maria SS.”, Troina, Italy;2. Department of Neurology, Paracelsus Klinik, Osnabrueck, Germany;3. Department of Clinical Neurophysiology, CHU de Bordeaux, Bordeaux, France;4. CNRS, INCIA, CNRS UMR 5287, Université de Bordeaux, Bordeaux, France;5. Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China;6. Department of Clinical Neurophysiology, University Medical Center, Georg August University Göttingen, Göttingen, Germany;1. Johns Hopkins Research Institute, Asthma& Allergy Bldg 1B76b, 5501 Hopkins Bayview Blvd, Baltimore, MD 21224, USA;2. Neurology Research, 115 Broadway, Bio 6, Biogen, Cambridge, MA 02142, USA;3. Department of Genetics, Genomics and Informatics, University of Tennessee, Memphis, TN, USA;4. Department of Neurology, College of Medicine, University of Florida, Gainesville, Florida 32610, USA;5. Sleep Center, Neurocenter of Southern Switzerland, Civic Hospital of Lugano, Lugano, Switzerland;6. Program in Sleep, Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA;7. Institute of Neurogenomics, Helmholtz Zentrum München, Munich, Germany;1. Sleep Research Centre, Department of Neurology I.C., Oasi Institute for Research on Mental Retardation and Brain Aging (IRCCS), Troina, Italy;2. Department of Neurology, Yale University School of Medicine, New Haven, CT, USA;3. University of Illinois College of Medicine at Urbana-Champaign and Carle Foundation Hospital, Urbana, IL, USA;4. Sleep and Epilepsy Center, Neurocenter of Southern Switzerland, Civic Hospital (EOC) of Lugano, Lugano, Switzerland |
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| Abstract: | In the 20 years since the initial consensus on a common definition for restless legs syndrome (RLS), over 600 scientific reports on epidemiological aspects of RLS have been published. Most are descriptive and address important issues such as prevalence, familial patterns, comorbidities, and quality of life. While the establishment of prospective cohort studies and the use of secondary data sources are rather new to RLS research, both options significantly broaden the possibilities for analysis of disease risk factors. These two options, as well as the inclusion of a broader phenotyping of individual patients, have great potential to elucidate etiologic factors for RLS and expand knowledge about this common disorder. This article summarizes achievements in the area of RLS epidemiology, describes current challenges, and highlights future perspectives in the field. |
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| Keywords: | Restless legs syndrome Study design Research methods Secondary data analysis Epidemiology |
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