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Real-time light dosimetry for intra-cavity photodynamic therapy: Application for pleural mesothelioma treatment |
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| Affiliation: | 1. Department of Analytic Human Pathology, Graduate School of Medicine Nippon Medical School, Tokyo, Japan;2. Department of Diagnostic Pathology, Teikyo University Mizonokuchi Hospital, 3-8-3 Mizonokuchi, Takatsu-ku, Kawasaki, Kanagawa, Japan;3. Department of Thoracic Surgery, Graduate School of Medicine Nippon Medical School, Tokyo, Japan |
| Abstract: | Complete and homogeneous illumination of the target is necessary for the success of a photodynamic therapy (PDT) procedure. In most applications, light dosimetry is done using detectors placed at strategic locations of the target. In this study we propose a novel approach based on the combination of light distribution modeling with spatial localization of the light applicator for real time estimation and display of the applied dose on medical images. The feasibility approach is demonstrated for intrapleural PDT of malignant pleural mesothelioma. |
| Keywords: | Photodynamic therapy Intra-cavity application Light distribution modeling Dosimetry Real time tracking Imaging |
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