辛伐他汀联合烟酸改善脂代谢异常疗效观察

目的随机对比观察脂代谢异常使用辛伐他汀和辛伐他汀加烟酸改善脂代谢的疗效、用药安全性及近期心血管事件的影响。方法所有临床确定的脂代谢异常患者入院后24h内采空腹静脉血测血脂等生化指标，对脂代谢异常的患者则按随机化原则分别入选辛伐他汀10mg组（对照组）与辛伐他汀10mg加烟酸0．3g组（治疗组）。对照组68例患者，其中男性43例，女性25例；平均年龄59．8岁。治疗组72例患者，其中男性46例，女性26例；平均年龄60．1岁。分别于服药后3、6、9个月复查血脂并对临床事件做登记，同时观察用药安全性。结果两组均能有效降低脂代谢异常患者血清TG、TC及LDL-C水平，其中治疗组降低TG、TC及LDL-C疗效优于对照组且明显升高HDL-C水平。结论他汀类药物与烟酸联合治疗脂代谢紊乱的疗效显效。

Curative Effect Observation of Simvastatin and Nicacid in Improving Lipid Metabolism Disorder

Objective To observe curative effect, security and influence on heart blood vessel recently of that lipid metabolism disorder patients with simvastatin as well as simvastatin and nicacid in improve lipid metabolism respectively. Methods All final diagnosed lipid metabolism disorder patients were measured in biochemical indicators such as blood fat of venous blood in the condition of empty stomach within 24h. The patients were divided into simvastatin 10mg group（control group） and simvastatin 10mg and nicacid 0.3g group（treatment group） randomly. Control group（68 patients） had 43 males and 25 females; its mean age was 59.8 years old. Treatment group（72 patients） had 46 males and 26 females; its mean age was 60.1 years old. We rechecked blood fat, recorded heart blood vessel incidents and observed security after 3,6,9 monthes respectively. Results Two groups could both effectively lower TG, TC and LDL-C of lipid metabolism disorder patients serum, and curative effect of treatment group was better than control group. Treatment group could still step up HDL-C obviously. Conclusion Curative effect of simvastatin and nicacid for lipid metabolism disorder is significant.