成人双侧输尿管炎症性肌纤维母细胞瘤1例报告并文献复习

目的介绍成人双侧输尿管炎症性肌纤维母细胞瘤（IMT）的病因、临床、病理特点和诊治方法及预后，提高对该病的认识。方法报告1例成人双侧输尿管炎症性肌纤维母细胞瘤病例。结合文献探讨本病病因、临床表现、诊断、治疗及预后。结果患者男性，59岁，双侧腰痛半月人院。影像学检查提示双侧输尿管下段占位性病变。手术完整切除双侧肿瘤，行输尿管膀胱再植术。术后病理诊断为双侧输尿管炎症性肌纤维母细胞瘤，免疫组化显示ALK（灶状4-），SMA（＋），vimentin（＋），CD34（-），desmin（-），S-100（-）。随访3月未见肿瘤复发及转移。结论成人双侧输尿管IMT罕见。临床难与输尿管恶性肿瘤鉴别，确诊需依靠病理，手术完整切除肿瘤是目前有效治疗方法。

Inflammatory myofibroblastic tumor of bilateral ureters in adult(a case report and literatures review)

Objective To introduce the etiological, clinical, pathological features of inflammatory myofibroblastic tumor of bilateral ureter in adult, and to discuss its diagnosis, treatment and prognosis. Methods A case of adult inflammatory myofibroblastic tumor of bilateral ureter was reported. The related literature, the etiology, and clinical features, diagnosis, treatment and prognosis of this disease were reviewed. Results After the 59-years-old patient suffered plain in bilateral lumbar regions for half a month, imaging examinatons showed occupying lesion located at the distal portion of each ureter. Tumors were completely resected during operation, and ureteroneocystostomy was performed. The post-operative pathological examination confirmed the diagnosis of inflammatory myofibroblastic tumor of bilateral ureters. Immunohistochemical staining showed ALK（ focal ＋ ）, SMA（ ＋）, vimentin（ ＋）, CD34 （ - ）, desmin（-）, and S- 100 （ - ）. The patient was followed-up for 3 months, with no recurrence and metastasis were observed. Conclusion As inflammatory myofibroblastic tumor of bilateral ureters in adult is rarely seen, it＇s hard to be distinguished from malignant tumor of ureter in clinic, Therefore, the accurate diagnosis mainly depends on pathological means. Currently, complete excision is the effective therapeutic method for such disease.