| 昂丹司琼的合成工艺改进 |
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| 引用本文： | 徐继曾,富强,李铭东,陈峻青,吉民. 昂丹司琼的合成工艺改进[J]. 药学与临床研究, 2005, 13(3): 15-17 |
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| 作者姓名： | 徐继曾 富强 李铭东 陈峻青 吉民 |
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| 作者单位： | 东南大学制药工程研究所,南京,210096 |
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| 摘 要： | 目的改进昂丹司琼的合成工艺。方法以1,2,3,9四氢4H咔唑4酮经N甲基化、Mannich反应和缩合得止吐药昂丹司琼。结果取得较佳的工艺条件,总收率为43.9%。结论该方法易于工业化生产。
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| 关 键 词： | 昂丹司琼 止吐药 合成 |
| 文章编号： | 1007-306(2005)03-15-03 |
| 修稿时间： | 2005-04-25 |
Improved Synthesis of Ondanstron |
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| XU Ji-zeng,FU Qiang,LI Ming-dong,CHEN Jung-qing,JI Min. Improved Synthesis of Ondanstron[J]. Pharmacertical and Clinical Research, 2005, 13(3): 15-17 |
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| Authors: | XU Ji-zeng FU Qiang LI Ming-dong CHEN Jung-qing JI Min |
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| Affiliation: | Nanjing 210096 |
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| Abstract: | AIM To improve the syntesis process of Ondansetron.METHODS Antiemetic Ondansetron was synthesized from 1,2,3,9-tetrahydro-4H-carbazol-4-one via N-methylation,Mannich reaction and condensation.RESULTS The suitable conditions were obtained,and the total yield was increased to 43.9%.CONCLUSION The process is practical and easy to popularize in industry. |
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| Keywords: | Ondansetron Antiemetic Synthesis |
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