可逆型质子泵抑制剂的研究进展

酸相关性疾病是消化道由于胃酸作用而诱发或导致的疾病,包括消化性溃疡、胃食道反流病等常见多发病。自第一个质子泵抑制剂奥美拉唑于1988年上市以来,质子泵抑制剂已成为酸相关性疾病治疗的首选药物,其缺点是起效慢、抑酸不彻底。可逆型的质子泵抑制剂口服起效快,疗效与剂量线性相关,副作用少成为了治疗消化性溃疡疾病的新方向。文中主要对近年来有关可逆性质子泵抑制剂的研究情况作一介绍。

Advances in the researches of reversible proton pump inhibitors

Acid-related diseases,including gastroesophageal reflux disease(GERD),peptic ulcer and other common illnesses,is mainly caused by the over-secretion of gastric acid.Since the first proton pump inhibitor(PPIs) omeprazole,came into the market in 1988,PPIs have been considered as the drugs of first choice for treatment of patients with various acid-related diseases.Despite the documented efficacy of the PPIs,therapeutic doses have a gradual onset of effect and do not provide complete symptom relief in all patients.Reversible proton pump inhibitions with rapid onset,less side effects,and linear dose-dependent pharmacokinetics,have been a new way to treat peptic ulcer-related disorders.This paper summarized the research progress of reversible PPIs in recent years.