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Heterogeneous in vitro effects of doxorubicin on gene expression in primary human liposarcoma cultures |
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| Authors: | Adrien Daigeler Ludger Klein-Hitpass Ansgar Michael Chromik Oliver Müller Jörg Hauser Heinz-Herbert Homann Hans-Ulrich Steinau Marcus Lehnhardt |
| Affiliation: | 1.Department of Plastic Surgery, Burn Center, Hand surgery, Sarcoma Reference Center, BG-University Hospital Bergmannsheil,Ruhr University Bochum,Bochum,Germany;2.Institute of Cell Biology (Tumor Research), IFZ, University of Essen,Essen,Germany;3.Department of Surgery,St. Josef Hospital, Ruhr-University,Bochum,Germany;4.Tumor Genetics Group, Max-Planck-Institut für molekulare Physiologie,Dortmund,Germany |
| Abstract: | BackgroundDoxorubicin is considered one of the most potent established chemotherapeutics in the treatment of liposarcoma; however, the response rates usually below 30%, are still disappointing. This study was performed to identify gene expression changes in liposarcoma after doxorubicin treatment. |
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