回顾性分析357例次小儿抗癫痫药物血药浓度

目的:回顾性分析4种常用抗癫痫药在儿童癫痫治疗中的血药浓度监测情况,以利指导合理用药。方法:采用HPLC法测定丙戊酸钠、卡马西平、苯巴比妥和苯妥英钠4种常用抗癫痫药物的血药浓度。结果:血药浓度在治疗窗内占47.1%,高于治疗窗占7.0%,低于治疗窗占45.9%。常规服药的患者有49.8%血药浓度在治疗窗内,联合用药致血药浓度偏离治疗窗达76.2%。结论:儿童使用抗癫痫药物监测血药浓度是指导临床用药的重要依据,特别是联合用药尤其应密切监测。

Antiepileptic drug serum concentration analysis: Retrospective study of 357 children's cases

Objective:The results of serum concentration monitoring of 4 antiepileptic drugs with 357 measurements in 164 epilepsy children were evaluated in order to guide clinical rational administration of these antiepileptic drugs. Methods:The serum concentration of antiepileptic drugs sodium valproate (VPA) , carbamazepine (CBZ),sodium phenytoin (PHT) and phenobarbital (PB) were monitored by HPLC. Results:The rate of serum concentrations which were in theraputic window is 47. 1% ,and which were lower and higher Than theraputic window are 45.9% and 7.0% respectively. The serum concentrations in normal range are founded in only 49. 8% of all patients by routine administration, and deviate from normal range by 76. 2% in combination with other drugs. Conclusion: Serum concentration monitor is an important basis for the treatment of children' s epilepsies with antiepileptic drugs, especially in combination with other drugs.