维他命E联合碳酸钙及阿司匹林对妊娠期高血压孕妇干预效果研究

目的探讨维他命E联合阿司匹林及碳酸钙对孕妇妊娠期高血压的干预效果。方法选取2010年4月至2013年4月我院接收治疗的300例妊娠期高血压高危孕妇,按照就诊先后顺序均分为对照组及治疗组。对照组给予常规生活指导,治疗组在对照组基础之上给予维他命E、碳酸钙、阿司匹林联合治疗。对比两组重度妊高征发生率,合并早产、产后出血的并发症发生率,剖宫产率,胎儿生长受限率以及治疗前/治疗20 d后血压变化率。结果治疗组及对照组重度妊高征发生率分别为2.67%(4/150)、11.33%(17/150);孕妇剖宫产率治疗组及对照组分别为38.00%(57/150)、73.33%(110/150);治疗组早产3例、产后出血4例,并发症发生率为4.67%(7/150),对照组早产21例、产后出血18例,并发症发生率26.00%(39/150);对照组、治疗组胎儿生长受限率分别为8.00%(12/150)、1.33%(2/150);治疗组治疗前后血压变化率显著高于对照组,两组比较差异有统计学意义(P<0.05)。结论维生素E联合碳酸钙及阿司匹林能够显著降低妊娠期高血压孕妇妊高征发生率、并发症发生率、剖宫产率以及胎儿生长受限率,效果显著,值得临床推广。

Intervention of vitamin E combined with calcium carbonate and aspirin on patientswith hypertensive disorder complicating pregnancy

Objective To investigate the intervention of vitamin E combined with calcium carbonate and aspi- rin on patients with hypertensive disorder complicating pregnancy. Methods 300 cases of high-risk pregnant women with gestational hypertension in our hospital from April 2010 to April 2013 were selected, and were divided into control group and treatment group in accordance with the order of treatment. Control group received routine life guidance, treat- ment group were given vitamin E, calcium and aspirin therapy on the basis of control group. The incidence of severe PIH, merge premature birth, postpartum hemorrhage rate, cesarean section rate, rate of fetal growth restriction of the two groups as well as the rate of change of blood pressure before and after 20 days treatment were compared. Results The incidence of severe PIH of treatment group and control group were 2. 67% （4/150） and 11.33% （17/150） ;maternal cesarean section rate in treatment group and control group were 38.00% （57/150） and 73.33% （110/150） ;treatment group had 3 cases of postpartum and 4 cases of hemorrhage, the complication rate was 4. 67 % （7/150） , control group had 21 cases of premature delivery, 18 cases postpartum hemorrhage,the complication rate was 26. 00% （39/150） ;fe- tal growth restriction rate of control group and treatment group were 8.00% （12/150） and 1.33% （2/150） ;the chan- ges in blood pressure before and after treatment of treatment group were significantly higher than those of control group, there were significant differences between the two groups （ P 〈 0. 05 ）. Conclusion Vitamin E combined with calcium carbonate and aspirin can significantly reduce the incidence of PIH maternal gestational hypertension, the inci- dence of complications, cesarean rate, and rate of fetal growth restriction, the effect is significant, it is worthy of promo- tion.