| 肺癌体外药敏试验与临床疗效之间的关系 |
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| 引用本文： | 邹青峰,楮忠华,马磊,李志彪,李卫东,陈文晟,金川,吴迪.肺癌体外药敏试验与临床疗效之间的关系[J].广州医药,2006,37(1):24-27. |
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| 作者姓名： | 邹青峰 楮忠华 马磊 李志彪 李卫东 陈文晟 金川 吴迪 |
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| 作者单位： | 广州医学院临床肿瘤中心、广州市肿瘤医院,510095;中山大学附属第二医院,510120 |
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| 摘 要： | 目的研究肺癌体外化疗药物敏感性与临床疗效的关系,为临床化疗方案的个体化选择提供依据.方法 60例非小细胞肺癌病例入组,试验组使用ATP-TCA方法测定肺癌组织中肿瘤细胞的化疗药物敏感性,并依据敏感结果选择化疗方案;对照组选择NP方案.观察临床近期疗效和远期生存率.结果试验组有效率43.48%,2年生存率34.78%,高于NP方案组的37.04%和25.92%,但是两组之间没有明显差异.结论依靠体外药敏试验结果指导化疗方案的制定可能有助于肺癌化疗疗效的提高.
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| 关 键 词： | 非小细胞肺癌 药敏实验 药物疗法 个体化疗 |
| 收稿时间： | 12 12 2005 12:00AM |
| 修稿时间： | 2005-12-12 |
Apllication of adenosine triphosphate tumor chemosensitivity assay to individual chemotherapy for non-small-cell lung cancer |
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| Zou Qinfeng, Chu Zhoughua, Ma Lei ,et al..Apllication of adenosine triphosphate tumor chemosensitivity assay to individual chemotherapy for non-small-cell lung cancer[J].Guangzhou Medical Journal,2006,37(1):24-27. |
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| Authors: | Zou Qinfeng Chu Zhoughua Ma Lei |
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| Institution: | Zou Qinfeng, Chu Zhoughua, Ma Lei , et al. |
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| Abstract: | Objective Evasluate the adenosine triphosphate tumor chemosensitivity assay(ATP-TCA) in guiding clinical chemotherapy for non-small-cell lung cancer(NSCLC) patients.Methods ATP-TCA was applied to test efficacies of 15 different drugs.23 patients received ATP-TCA-directed chemotherapy;the other 27 patients received NP regimen(control group).Clinical outcome were observed.Results ATP-TCA group have the response rate of 43.38%,a little higher than the control group of 37.04%.The 2-year over all survival rate is 34.78% in ATP-TCA group and 25.92% in control group.Conclution ATP-TCA might be useful in planning individualized chemotherapy regimen for NSCLC patients. |
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| Keywords: | Non-small-cell lung cancer Chemo-drug sensitive test Drug therapy Individual treatment |
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