血清淀粉样蛋白A与冠心病的相关性研究

目的 调查广州市石牌村老年人群血清淀粉样蛋白A（amyloid A，SAA）水平与冠心病之间的关系。方法 从该村原居民老年人群血清标本950份，随机抽取161份，应用酶联免疫吸附法测量其SAA水平。将其分为有冠心病史组（22例）与无冠心病史组（139例）。按SAA水平分为低中高3组。结果 有冠心病史组SAA水平3106μg／L（ng／ml），95％置信区间291～5897μg／L；而无冠心病史组SAA水平756μg／L，95％置信区间184～3100μg／L，差异有统计学意义（P＜0.01）。SAA水平与冠心病的Logistic回归分析表明：随着SAA水平逐渐升高，冠心病危险性亦有显著性增加。结论 SAA水平与冠心病呈正相关。

The correlative study of the serum amyloid A levels and coronary heart disease

Objectives To study the relationship between the serum amyloid A (SAA) levels and coronary heart disease (CHD) in the elderly patients located in the combining area between city and country of Shipai. Methods The SAA levels were determined from 161 serum samples of 950 aboriginal elder, by enzyme-linked immunosorbent assay (ELISA). Individuals were divided into 2 groups:22 and 139 individuals with or without history of CHD respectively. According to the SAA levels, all individuals were divided into 3 groups:46 individuals with SAA level of 500 ng/ml or less, 59 individuals with SAA level from 500 to1000 ng/ml, 56 individuals with SAA level of 1000 ng/ml or more. Results The levels of SAA was 3106 ng/ml (95% confidence interval from 291 to 5897 ng/ml) in the group with history of CHD, while were 756 ng/ml ( 95% confidence interval from 184 to 3100 ng/ml)in the group without CHD history, which has significant statistic difference. The logistic regression indicated the risk of coronary heart disease increased as SAA levels increased. Conclusions The SAA levels are correlative significantly to the risk of coronary heart disease.