| Heymann抗原（Tub—Ag）的提取鉴定及其所致肾炎的临床病理学观察 |
| |
| 引用本文： | 王迎伟,张建民,等.Heymann抗原（Tub—Ag）的提取鉴定及其所致肾炎的临床病理学观察[J].徐州医学院学报,1990,10(1):1-6. |
| |
| 作者姓名： | 王迎伟 张建民 |
| |
| 作者单位： | [1]徐州医学院微生物学教研室 [2]南京铁道医学院病理室 |
| |
| 摘 要： | 从大鼠小管刷状缘微绒毛上提取了小抗原（Tub-Ag)，并用动物实验鉴定出经Bio-GelA1.5m(100-200mesh)过滤洗脱的Tub-Ag所致肾炎性片段（C峰蛋白）。大鼠接受峰抗原免疫后可产生典型的主动性HeymannT肾炎，观察该肾炎病演变过程发现：其临床及病理学变化十分类似人类膜性肾小球肾炎。提示：用Tub-Ag免疫所致的大鼠Heymann肾炎确为研究膜性肾炎的良好模型之一。
|
| 关 键 词： | 小管上皮抗原 Heymann肾炎 膜性肾炎 病理学 |
ISOLATION AND CHARACTERIZATION OF THE HEYMANN ANTIGEN ( TUB-AG ) AND CLINICOPATHOLOGIC OBSERVATION OF THE HEYMANN NEPHRITIS |
| |
| Wang Yingwei.ISOLATION AND CHARACTERIZATION OF THE HEYMANN ANTIGEN ( TUB-AG ) AND CLINICOPATHOLOGIC OBSERVATION OF THE HEYMANN NEPHRITIS[J].Acta Academiae Medicinae Xuzhou,1990,10(1):1-6. |
| |
| Authors: | Wang Yingwei |
| |
| Abstract: | In this experiment , tubular epithelial antigen (Tub-Ag) from renal tubular brush border microvillus membranes of normal rats was isolated. And nephritogenic fractions ( protein in peak C ) of Tub-Ag by gelfiltration on Bio-Gel A 1.5m ( 100-200mesh ) were eharacterized by animal experiment. The rats received injection of peak C developed a typical features of active Heymann nephritis. The observation on the developing course of the Hey-mann nephritis indicated that the clinicopathologic changes of it closely resemble that of human membranous glomerulonephritis. The results suggest that the Heymann nephritis induced by immunizing rats with the homologous Tub-Ag is a relatively better laboratory model on the study of membranous nephritis. |
| |
| Keywords: | tubular epithelial antigen Heymann nephritis membra-nous nephritis pathology |
| 本文献已被 CNKI 维普 等数据库收录！ |
