腹腔镜胆囊切除与剖腹胆囊切除术对高血压患者血管内皮素和C反应蛋白的影响

为探讨剖腹与腹腔镜胆囊切除术 2种方法对高血压合并胆囊疾病患者血中内皮素和 C反应蛋白的影响 ,比较两种方法对机体损伤的程度及安全性 ,选择行剖腹胆囊切除术高血压患者 15例 ,腹腔镜胆囊切除术高血压患者 15例 ,无高血压腹腔镜胆囊切除术患者 15例 ,分别于术前、术中、术后 3h,12 h,2 4h抽取静脉血检测内皮素、C反应蛋白含量并进行比较。结果表明 :剖腹胆囊切除术高血压患者血中内皮素术中、术后含量明显高于腹腔镜胆囊切除术患者 (P<0 .0 1) ,C反应蛋白于术后 12 h明显高于腹腔镜胆囊切除术高血压患者。研究表明腹腔镜胆囊切除术刺激小 ,对高血压患者较为安全。

The Influence of Laparoscopy Cholecystectomy and Open Cholecystectomy on the Contents of Endothelin and C-Reactive Protein in Patients with Hypertension

The effect of laparoscopy cholecystectomy (LC) and open cholecystectomy (OC) on the plasma contents of endothelin (ET) and C reactive protein (CRP) in the patients with hypertension was investigaed. The concentrations of ET and CRP were determined in the blood samples before and during operation, 3, 12, 24 h after operation in the hypertention patients undergoing OC (OC group, n =15), hypertension patients undergoing LC (LC1 group, n =15), and the non hypertension patients undergoing LC (LC2 group, n =15). The levels of ET were significantly increased during operation in the three groups and those in OC group were higher than in LC1 and LC2 groups ( P <0.01). CRP was significantly increased 3 h after operation in the three groups and the levels in OC group were higher than in LC1 and LC2 groups ( P <0.01), but no difference in CRP level between LC1 and LC2 groups was found. It was indicated that LC was safer to the patients with hypertension than OC.