雷贝拉唑三联疗法根除Hp临床观察

目的　观察以雷贝拉唑、左氧氟沙星、阿莫西林三联疗法对Hp治疗失败后的患者复治的疗效。方法　 3 7例经胃镜检查证实为慢性胃炎患者 ,均在 1月前抗Hp治疗 ,每位患者同时具有C14 呼气试验阳性及金标免疫斑点法检测Hp抗体阳性。分为两组 :A组 2 0例 ,雷贝拉唑 10mg每日 2次 ,左氧氟沙星 0 2每日 2次 ,阿莫西林 1g每日 2次 ,疗程 7天 ;B组 17例 ,雷贝拉唑 10mg每日 2次 ,胶体果胶铋 15 0mg每日 2次 ,甲硝唑 40 0mg每日 2次 ,四环素 5 0 0mg每日 4次 ,疗程 7天。治疗结束后 4周及 8周时重复做C14 呼气试验 ,以确定Hp是否根除。同时于用药前后对患者的上腹痛、饱胀不适、嗝气、反酸症状进行评估。结果　A组Hp根除率 85 % ;B组Hp根除率 88 2 3 %。两组Hp根除率比较无统计学意义(P >0 0 5 ) ;两组治疗前各症状积分差异无统计学上意义 ,治疗后上腹痛症状积分下降 ,差异有统计学意义 (P <0 0 5 ) ,其余症状在治疗后积分下降 ,差异无统计学意义 (P >0 0 5 ) ,两组患者治疗后各症状积分下降值差异无统计学意义 (P >0 0 5 )。结论　以雷贝拉唑联用左氧氟沙星、阿莫西林的三联疗法对Hp治疗失败后的Hp根除率与以雷贝拉唑的四联疗法对Hp的根除率接近 ,慢性胃炎的症状缓解程度相同 ,且用药简单 ,患者易于接受

A clinic study of Rabeprazole tri-binding treatment for eradicate H.pylori

Objective To observe the efficacy of a combined treatment using Rabeprazole,Amoxycillin and Levofloxain Hydrochloide Capsules for those H.pylori infected patients who had uncured by other methods.Methods 37 cases were chosen,who were uncured by other anti-Hp treatments a month ago,and determined to be positive by UBT and ELISA.These cases be classed into A and B groups.Group A has 20 cases,treated by Rabeprazole 10mg bid,Amoxycillin lg bid,and Levofloxain Hydrochloide Capsules 0.2 bid respectively,and the treated program lasted 7 days.Group B has 17 cases,treated by Rabeprazole 10mg bid,Colloidal Bismuth Pectin Capsules 150mg tid,Metronidazole 400mg bid,Teracycline 500mg qid respectively,and has same treatment time with group A.The UBT tests were hold to determine whether the positive of H.pylori still existence.At same time,the symptoms of these cases before and after treatment were evaluated.Results The eradicate rate of the positive of H.pylori is 85% in group A and 88.23% in group B,respectively.Conclusions Group A(treated with Rabeprazole,Amoxycillin and (zf))and Group B(treated with Rabeprazole,Colloidal Bismuth Pectin Capsules,Metronidazole and Tetracycline)have the same treatment efficacy,there is not much deference between the two treatment methods.