MCM5和PCNA在鼻咽低分化鳞癌中的表达及意义

目的：检测鼻咽低分化鳞癌组织中微小染色体维持蛋白5（MCM5）的表达意义及与细胞增殖核抗原（PCNA）的关系。方法：采用免疫组织化学S-P法检测50例鼻咽低分化鳞癌、20例鼻息肉组织中MCM5及PCNA的表达情况。结果：MCM5与PCNA在鼻咽低分化鳞癌中的表达均高于鼻息肉组织（P〈0．01）；鼻咽低分化鳞癌中，MCM5的表达高于PCNA（P〈0．05），两者之间呈正相关（r=0．8397，P〈0．01）；MCM5与PCNA在鼻咽低分化鳞癌中的表达在性别、年龄、淋巴结转移方面的差异不具有统计学意义（P〉0．05）。结论：MCM5在鼻咽癌组织中高表达，可作为鼻咽低分化鳞癌的标志物。

Expression of minichromosome maintenance protein 5 and PCNA in NPC and its significance

Objective： To study the expression of minichromosome maintenance protein 5 （MCMS） in nasopharyngeal carci noma tissue and its significance, and to analyze the correlation between MCM5 and PCNA. Methods：The expression of MCM5 and PCNA were detected with Streptavidin-Peroxidase （S-P）. Results： The expressions of MCM-5 and PCNA were both higher in cancer than those in tissues of rhino polypus, and the labeling index of MCM5 in nasopharyngeal carcinoma was higher than that of PCNA. A positive correlation was found between MCM5 and PCNA. Labeling index of MCM5 showed no significant correlation with patient age, gender, and lymph node metabasis. Conclusion： MCM5 has a high expression in nasopharyngeal carcinoma tissue and it is more sensitive than PCNA as an indicator for pathological diagnosis of NPC.