| 正电子显影剂^18F-FDG快速自动化合成及其质量控制 |
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| 引用本文： | 李琳,孙华,黄飞杰,李敏聪,王继良.正电子显影剂^18F-FDG快速自动化合成及其质量控制[J].昆明医学院学报,2009,30(12):56-58. |
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| 作者姓名： | 李琳 孙华 黄飞杰 李敏聪 王继良 |
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| 作者单位： | 1. 昆明医学院第三附属医院,云南省肿瘤医院PET/CT中心,云南,昆明,650018
2. 昆明医学院,云南省天然药物药理重点实验室,云南,昆明,650031 |
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| 摘 要： | 目的研究正电子断层显像剂2-18F-2-脱氧-D-葡萄糖（18F-FDG）的快速自动化合成与质量控制.方法采用日本住友Sumitomo HM-10回旋加速器,通过18O（p,n）18F核反应和亲核取代反应制备18F-FDG.对制备的18F-FDG进行质量控制研究.结果合成效率大于55%,用TLC法和HPLC法测定化学纯度大于95%,放化纯度大于99%,18F-FDG各项质量控制指标符合药典要求.结论制备的18F-FDG适用于临床.
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| 关 键 词： | F-FDG 快速自动化合成 质量控制 放射化学纯度 合成效率 正电子断层显像 回旋加速器 核反应 放射性药物 制备 |
Rapidly Automated Synthesis and Quality Control of Positron 20-18F-fluoro-2-deoxy-D-glucose as a Positron Emission Tomograghy Imaging Agent |
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| LI Lin,SUN Hua,HUANG Fei-jie,LI Min-cong,WANG Ji-liang.Rapidly Automated Synthesis and Quality Control of Positron 20-18F-fluoro-2-deoxy-D-glucose as a Positron Emission Tomograghy Imaging Agent[J].Journal of Kunming Medical College,2009,30(12):56-58. |
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| Authors: | LI Lin SUN Hua HUANG Fei-jie LI Min-cong WANG Ji-liang |
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| Institution: | LI Lin,SUN Hua,HUANG Fei-jie,LI Min-cong,WANG Ji-liang(1) PET/CT Center,The 3rd Affiliated Hospital of Kunming Medical University,Tumor Hospital of Ynnan province,Kunming Yunnan 650018;2) Yunnan Key Laboratory of Pharmacology for Natural Products,Kunming Medical University,Kunming Yunnan 650031,China) |
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| Abstract: | Objective Toinvestigate rapidly automated synthesis and qaulitycontrol of2-deoxy-2-18F-fluoro-D-glucose（^18F-FDG）,which is a positron emission tomograghy imaging agent.Methods 18F-FDG was synthesized via nuclear reacion ^18O（p,n） ^18F and on 18O-en-riched water and nucleophilic substitution reaction by Sumitomo HM-10 cyclotron system.We also investigated the quality control of ^18F-FDG.Results The product yield was above 55%,the chemical and radiochemical purity was above 95% and 99% by high-performance liquid chromatograghy and thin-layer chromatograghy respectly.The quality control parameters of ^18F-FDG were standard.Conclusion High-quality ^18F-FDG prepared in this paper is suitable for clinical performance of PET. |
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| Keywords: | 18F-FDG |
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