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Peritoneal VEGF burden as a predictor of cytoreductive surgery outcome in women with epithelial ovarian cancer |
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| Authors: | Solange Maria Diniz Bizzo Débora Dummer Meira José Marinaldo Lima José Cláudio Casali-da-Rocha |
| Institution: | a Gynecologic Oncology Service of National Cancer Institute, Brazil b Division of Clinical Research of National Cancer Institute, Brazil c Department of Biochemistry of the State University of Rio de Janeiro, Brazil d National Tumor Bank of the Research Center of National Cancer Institute, Brazil e Department of Pathology of the State University of Rio de Janeiro, Brazil f Bone Marrow Unit of the National Cancer Institute, Brazil |
| Abstract: | ObjectiveTo determine whether peripheral plasma concentration, peritoneal fluid concentration, and/or peritoneal vascular endothelial growth factor (VEGF) burden can predict the possibility of optimal cytoreduction in women with epithelial ovarian carcinoma (EOC); and if so, to determine cutoff values below which optimal cytoreduction is likely to occur.MethodsWe measured plasma VEGF concentration, peritoneal VEGF concentration, and VEGF burden in 46 women undergoing cytoreductive surgery. Univariate analysis, bivariate analysis, correlation tests, and stepwise regression were performed with cytoreduction as the outcome.ResultsThe VEGF burden best predicted the outcome. The area under the curve was 0.84 and the log-transformed cutoff value was 15.52 log pg. Overall, the chance of optimal cytoreduction was 11 times greater when the VEGF burden was less than 15.52 log pg. For women with advanced disease, the chance was 6 times greater below this value.ConclusionThe VEGF burden may quantify tumor activity, and it could be used when selecting patients likely to benefit from induction chemotherapy before undergoing cytoreductive surgery. |
| Keywords: | Angiogenesis Ovarian cancer Prognosis Vascular endothelial growth factor |
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