罗格列酮对兔动脉粥样硬化血脂和组织总抗氧化能力的影响

目的:观察罗格列酮对高胆固醇饮食兔血脂和组织总抗氧化能力的影响,探讨罗格列酮对动脉粥样硬化斑块消退的机制。方法:雄性新西兰大白兔24只随机等分为3组:对照组、胆固醇组、罗格列酮组。罗格列酮从第10周开始干预,16周后,测定血脂、血糖水平,主动脉行病理形态学及颈动脉组织总抗氧化能力的检测。结果:与对照组和胆固醇组相比,16周末时罗格列酮组血清总胆固醇、低密度脂蛋白胆固醇均明显降低;主动脉壁斑块数量和斑块面积显著减少;颈动脉组织总抗氧化能力明显增强。结论:罗格列酮对动脉粥样硬化斑块消退作用的其机制之一可能与降低血清总胆固醇、低密度脂蛋白胆固醇水平及增强组织总抗氧化能力有关。

Effects of rosiglitazone on the serum lipids and total antioxidative abilities in atherosclerotic rabbits

Objective: To study the effects of rosiglitazone on the atherosclerotic plaque in rabbits. Method: Twenty-four male New Zealand white rabbits weighing 1. 8 to 2. 2 kg were randomly divided into 3 groups: control group (normal rabbits diet), cholesterol group (cholesterol diet), Rosiglitazone group (cholesterol diet supplemented with rosiglitazone since 10th week). Rabbits in cholesterol group and rosiglitazone group were sequentially fed 1% cholesterol-containing diet for 16 weeks. At the end of the experiment,blood glucose,serum lipids levels, ratio of plaque area to aorta area were measured and total antioxidative abilities were determinated with chroma-tometry. Result: Hypercholesterolemia was successfully induced. After rosiglitazone intervention, level of serum TC, LDL-C, and ratio of plaque area to aorta area had significant difference between cholesterol group and rosiglitazone group ( P <0. 05). Total antioxidative abilities were stronger in rosiglitazone group than those in cholesterol group. Conclusion:Our study showed rosiglitazone had effects on atherosclerotic plaque regression by decreasing levels of TC and LDL and increasing total antioxidative abilities of blood vessel.