Black (air-cured) and blond (flue-cured) tobacco and cancer risk I: Bladder cancer |
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| Institution: | 1. Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany;2. Institute of Medical Biometry and Informatics, University of Heidelberg, Im Neuenheimer Feld 130.3, D-69120 Heidelberg, Germany;3. Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 460, D-69120 Heidelberg, Germany;4. German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany;1. Department of Urology, Roswell Park Comprehensive Cancer Center, NY, USA;2. Department of Medical Oncology, Roswell Park Comprehensive Cancer Center, NY, USA |
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| Abstract: | Four case-control studies in different Latin countries have reported risks of bladder cancer 2–3 times higher for smokers of black (air-cured) than for smokers of blond (flue-cured) tobacco. This observation is interesting in the light of a higher concentration of arylamines in black tobacco. The relative risk dropped very rapidly after discontinuation of smoking, and there was also an effect of age at start, with higher risks associated with earlier onset of the habit. Overall, black tobacco seems to act both on early and late stages of bladder carcinogenesis. |
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