Potentiation of retinoid-induced differentiation of HL-60 and U937 cell lines by cytokines |
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| Affiliation: | 1. Department of Medical Laboratory, The Affiliated Huaian No. 1 People’s Hospital of Nanjing Medical University, Huai’an, Jiangsu 223300, China;2. Department of Stomatology, The Affiliated Huaian No. 1 People’s Hospital of Nanjing Medical University, Huai’an, Jiangsu 223300, China;1. Équipe de Recherche en Épidémiologie Nutritionnelle (EREN) – Inserm U1153, Inrae U1125, Cnam, université Sorbonne Paris Nord, Centre de Recherche Epidémiologie et Statistiques (CRESS), université de Paris, Bobigny, France;2. Réseau National Alimentation Cancer Recherche (NACRe, http://www.inrae.fr/nacre.), Jouy-en-Josas, France;3. Hôpital Avicenne, Département de Santé Publique, AP-HP, Bobigny, France;1. Institute of Ecology and Earth Sciences, University of Tartu, Tartu 51014, Estonia;2. Estonian Marine Institute, University of Tartu, Mäealuse 14, 12618 Tallinn, Harju County, Estonia;1. Institute of Infection and Global Health, University of Liverpool, Liverpool Science Park IC2, 146 Brownlow Hill, Liverpool L3 5RF, United Kingdom;2. Institute of Integrative Biology, University of Liverpool, Biosciences Building, Crown Street, Liverpool L69 7ZB, United Kingdom;3. NIHR Health Protection Research Institute in Emerging and Zoonotic Infections, Institute of Infection and Global Health, University of Liverpool, The Ronald Ross Building, 8 West Derby Street, Liverpool L69 7BE, United Kingdom |
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| Abstract: | Retinoids varied in their capacity to induce differentiation in HL-60 cells in this order: Ro 13-6307, tretinoin, isotretinoin, acitretin and Ro 13-7410 (high to low). In contrast, retinoids lacking a polar carboxylic acid, such as temarotene and Ro 14-6113, were inactive. Various cytokines had no differentiation-inducing effect by themselves. However, the addition of cytokines to retinoids increased differentiation. Combined with tretinoin, cytokines increased differentiation in this order: interferon (IFN) gamma, granulocyte colony-stimulating factor, interleukin-1α (IL-1α), IL-4, tumour necrosis factor alpha and IFN-α. Combination of cytokines with isotretinoin, acitretin, Ro 13-7410, and Ro 13-6307 showed a similar pattern of potentiation to that of tretinoin. Temarotene or Ro 14-6113 did not induce differentiation, alone or with cytokines. Combinations of cytokines were not synergistic in the presence of retinoids; antagonism was even observed. In U937 cells, lower levels of differentiation-induction were observed. Potentiation of the differentiation-inducing effect of retinoids by cytokines might indicate a clinical differentiation therapy of tumours. |
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