Tissue plasminogen activator and plasminogen activator inhibitor in patients with liver cirrhosis |
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| Affiliation: | 1. Department of Hematology, Hospital San Millán, Logroño, Spain;2. Department of Gastroenterology, Hospital Clinico Universitario, Zaragoza, Spain;3. Department of Physiology, University of León, Spain;1. Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA;2. Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA;1. Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China;2. Department of Central Laboratory, Shanghai Tenth People’s Hospital of Tongji University, School of Life Science and Technology, Tongji University, Shanghai 200072, China;3. Institute of Aging Research, Hangzhou Normal University, Hangzhou 311121, China;4. Department of Clinical Medicine, Shanghai Tenth People’s Hospital of Tongji University, Tongji University, Shanghai 200072, China;1. Area of Pharmacology and Nutrition & Bromatology, Department of Basic Health Sciences, Universidad Rey Juan Carlos, Alcorcón, Madrid, Spain;2. Area of Toxicology, Department of Pharmaceutical and Health Sciences, Universidad CEU San Pablo, Alcorcón, Madrid, Spain |
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| Abstract: | The behaviour of tissue plasminogen activator (t-PA) and t-PA inhibitor (PAI) was studied in patients with decompensated liver cirrhosis. t-PA antigen showed a 3-fold significant increase with respect to healthy volunteers. t-PA activity in these patients did not significantly differ from that found in the controls, but the specific activity of t-PA was significantly lowered by 63%. PAI activity was significantly reduced in cirrhosis (−67%), while PAI-1 antigen was increased by 24%. Venous occlusion of the arm for 20min induced similar increases of t-PA antigen both in normal subjects and cirrhotic patients. These findings show that the total amount of t-PA is enhanced in liver cirrhosis, with no increase of t-PA activity due to the capacity of PAI to bind increased circulating t-PA antigen. The increased total amount of t-PA in cirrhotic patients could be explained in terms of a reduced clearance by the hepato-endothelial system. |
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