Low-dose cytarabine for acute myeloid leukaemia and myelodysplastic syndromes: in vivo and in vitro cytotoxicity期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Low-dose cytarabine for acute myeloid leukaemia and myelodysplastic syndromes: in vivo and in vitro cytotoxicity

Affiliation:	1. Department of Haematology, Free University Hospital, De Boelelaan 1117, BR 238, 1081 HV Amsterdam, The Netherlands;2. Department of Medical Statistics, Free University Hospital, De Boelelaan 1117, BR 238, 1081 HV Amsterdam, The Netherlands;1. Department of Hygienic Chemistry, Meiji Pharmaceutical University, Japan;2. Meiji Pharmaceutical University, Japan;1. Division of Oncology, Washington University School of Medicine, St. Louis, MO, United States;2. Department of Pathology, Washington University School of Medicine, St. Louis, MO, United States;3. Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL, United States;4. Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, United States;1. Department of Anesthesiology, Fudan University Shanghai Cancer Center, No. 270, Dong an Road, Shanghai 200032, PR China;2. Department of Liver Surgery, Fudan University Shanghai Cancer Center, No. 270, Dong an Road, Shanghai 200032, PR China

Abstract:	14 patients with acute myeloid leukaemia (AML) and 7 with myelodysplastic syndrome (MDS) were treated with cytarabine in low dosage. In AML a complete remission rate of 43% was found and in all patients profound cytopenia was noticed without any sign of maturation induction. In MDS no effect of low-dose cytarabine could be detected. We also studied the effect of low-dose cytarabine in vitro in freshly isolated leukaemic cells of 10 patients with AML. Maturation induction was measured by a comprehensive panel of quantitative and qualitative markers of maturation. No differentiation inducing effect of low-dose cytarabine could be found. We conclude on the basis of our own results and after reviewing the literature that low-dose cytarabine exerts its effect by cytotoxicity instead of maturation induction.

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