MDR1 gene expression and prognostic factors in primary breast carcinomas |
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| Affiliation: | 1. University of Texas Health Science Center San Antonio, Department of Orthopaedics, 7703 Floyd Curl Dr, Mail code 7774, San Antonio, TX 78229-3900;2. University of Washington/Harborview Medical Center, Department of Orthopedics and Sports Medicine, Seattle, Washington, USA;1. Department of Neurology, National Neuroscience Institute, Singapore;2. Duke-NUS Medical School, Singapore;3. Department of Radiology, Khoo Teck Puat Hospital, Singapore |
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| Abstract: | To prospectively assess the role of the MDR1 gene in breast carcinomas, MDR1 RNA levels of breast carcinoma specimens were determined by slot blot analysis. In 59 evaluable patients with primary breast carcinomas, MDR1 RNA levels of the carcinomas were negative in 54%, low in 29% and high in 17% of the patients. No differences in age, menopause status, oestrogen and progesterone receptor levels, tumour size, lymph node involvement and c-erbB-2/neu gene expression were observed between MDR1 RNA negative patients and MDR1 RNA positive patients. |
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