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Use of phase analysis of gated SPECT perfusion imaging to quantify dyssynchrony in patients with mild-to-moderate left ventricular dysfunction |
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| Authors: | Allen E. Atchley MD Mark A. Trimble MD Zainab Samad MD Linda K. Shaw MS Robert Pagnanelli CNT Ji Chen PhD Ernest V. Garcia PhD Ami E. Iskandrian MD Eric J. Velazquez MD Salvador Borges-Neto MD |
| Affiliation: | (1) Division of Cardiology, Duke University Medical Center, Durham, NC, USA;(2) Duke Clinical Research Institute, Durham, NC, USA;(3) Department of Radiology, Division of Nuclear Cardiology, Duke University Medical Center, Durham, NC, USA;(4) Department of Radiology, Emory University School of Medicine, Emory University, Atlanta, GA, USA;(5) Department of Cardiology, University of Alabama at Birmingham, Birmingham, AL, USA;(6) Department of Internal Medicine, Division of Cardiology, Duke University Medical Center, Duke University, Durham, NC, USA;(7) Department of Radiology, Division of Nuclear Medicine, Duke University Medical Center, Durham, NC, USA |
| Abstract: | BackgroundCRT has been shown to be beneficial in the majority of patients with NYHA class III-IV symptoms, prolonged QRS duration, and an EF ≤35%. The use of imaging modalities to quantify dyssynchrony may help identify patients who may benefit from CRT, but do not meet current selection criteria. We hypothesize that patients with mild-to-moderate LV dysfunction have significant degrees of mechanical dyssynchrony. |
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