Ethanol extracts of Rehmannia complex (Di Huang) containing no Corni fructus improve early diabetic nephropathy by combining suppression on the ET-ROS axis with modulate hypoglycemic effect in rats期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Ethanol extracts of Rehmannia complex (Di Huang) containing no Corni fructus improve early diabetic nephropathy by combining suppression on the ET-ROS axis with modulate hypoglycemic effect in rats

Authors:	Liu Hao-Ran Tang Xiao-Yun Dai De-Zai Dai Yin

Institution:	Research Division of Pharmacology, China Pharmaceutical University, Nanjing, China.

Abstract:

Keywords:	DN diabetic nephropathy ESRD end-stage renal disease ET-1 endothelin-1 STZ streptozotocin AGEs advanced glycation end products BUN blood urea nitrogen MDA malondialdehyde GSH-px glutathione peroxidase SOD superoxide dismutase MMP matrix metalloproteinase ECM extracellular matrix ROS reactive oxygen species TNF tumor necrosis factor TGF transforming growth factor RC Rehmannia complex TCM Traditional Chinese Medicine AMG aminoguanidine TLC thin chromatography tNOS total nitric oxide synthase iNOS inducible nitric oxide synthase cNOS constitutive nitric oxide synthase NADPH reduced form of nicotinamide-adenine dinucleotide phosphate SDS PAGE sodium dodecyl sulphate polyacrylamide gel electrophoresis GAPDH glyceraldehyde phosphate dehydrogenase MAPK Mitogen-Activated Protein Kinase
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