| 皮瓣缺血-再灌注损伤的治疗 |
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| 引用本文： | 顾文奇,张巍,柴益民. 皮瓣缺血-再灌注损伤的治疗[J]. 中国修复重建外科杂志, 2011, 0(3): 373-376 |
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| 作者姓名： | 顾文奇 张巍 柴益民 |
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| 作者单位： | 上海交通大学附属第六人民医院骨科; |
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| 摘 要： | 目的综述皮瓣缺血-再灌注损伤治疗方法及技术。方法广泛查阅皮瓣缺血-再灌注损伤治疗技术的相关文献,对其治疗方法进行系统性综述。结果缺血-再灌注损伤是导致皮瓣术后坏死的主要因素之一。对缺血-再灌注损伤机制任一环节的干预均可有效减轻损伤,提高皮瓣术后成活率。结论皮瓣缺血-再灌注损伤的主要机制包括活性氧物质生成、中性粒细胞聚集、浸润等。可采用药物治疗、物理干预等方法对缺血-再灌注损伤中的某一或某些环节进行有效干扰或阻断,从而减轻动物皮瓣模型缺血-再灌注损伤,提高皮瓣成活率。
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| 关 键 词： | 皮瓣 缺血-再灌注损伤 预处理 抗氧化剂 白细胞抑制剂 |
TREATMENT OF ISCHEMIA-REPERFUSION INJURY OF FLAP |
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| GU Wenqi,ZHANG Wei,CHAI Yimin. TREATMENT OF ISCHEMIA-REPERFUSION INJURY OF FLAP[J]. Chinese journal of reparative and reconstructive surgery, 2011, 0(3): 373-376 |
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| Authors: | GU Wenqi ZHANG Wei CHAI Yimin |
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| Affiliation: | .Department of Orthopedics,the Sixth People’s Hospital,Shanghai Jiaotong University,Shanghai,200233,P.R.China. |
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| Abstract: | Objective To review the treatment methods and techniques of ischemia-reperfusion injury of flap.Methods Recent basic research literature concerning ischemia-reperfusion injury of flap was reviewed and analyzed in terms of treatment techniques.Results Ischemia-reperfusion injury is one of the leading causes of flap necrosis postoperatively.Interventions against any link of the ischemia-reperfusion injury progress could effectively reduce the damage and improve the survival rate of flaps.Conclusion Including ... |
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| Keywords: | Flap Ischemia-reperfusion injury Preconditioning Antioxidant Leukocyte inhibitor |
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