The VHL-dependent regulation of microRNAs in renal cancer |
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| Authors: | Calida S Neal Michael Z Michael Lesley H Rawlings Mark B Van der Hoek and Jonathan M Gleadle |
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| Institution: | (1) Renal Unit, School of Medicine, Flinders University, Flinders Medical Centre, Adelaide, Australia;(2) Department of Gastroenterology, School of Medicine, Flinders University, Flinders Medical Centre, Adelaide, Australia;(3) Familial Cancer Section, Department of Genetics and Molecular Pathology, IMVS, Adelaide, Australia;(4) Adelaide Microarray Centre, School of Molecular and Biomedical Sciences, University of Adelaide, Adelaide, Australia |
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| Abstract: | Background The commonest histological type of renal cancer, clear cell renal cell carcinoma (cc RCC), is associated with genetic and
epigenetic changes in the von Hippel-Lindau (VHL) tumour suppressor. VHL inactivation leads to induction of hypoxia-inducible
factors (HIFs) and a hypoxic pattern of gene expression. Differential levels of specific microRNAs (miRNAs) are observed in
several tumours when compared to normal tissue. Given the central role of VHL in renal cancer formation, we examined the VHL-dependent
regulation of miRNAs in renal cancer. |
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