| 大剂量γ射线对小鼠造血功能损伤的比较研究 |
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| 引用本文： | 吴红英,王月英,李德冠,王小春,张恒,路璐,常建辉,杜利清,王彦,孟爱民.大剂量γ射线对小鼠造血功能损伤的比较研究[J].中国辐射卫生,2010,19(4):403-404. |
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| 作者姓名： | 吴红英 王月英 李德冠 王小春 张恒 路璐 常建辉 杜利清 王彦 孟爱民 |
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| 作者单位： | 中国医学科学院北京协和学院放射医学研究所,天津市分子核医学重点实验室,天津,300192 |
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| 基金项目： | 国家自然科学基金,天津市自然科学基金,中国医学科学院青年基金,放射所发展基金 |
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| 摘 要： | 目的探讨大剂量电离辐射对IRM-2小鼠、C57BL/6 J小鼠造血功能损伤及恢复的比较。方法用137Csγ射线分别对IRM-2小鼠、ICR小鼠进行4.0Gy照射,照后9d,检测小鼠造血功能三项(脾指数、CFU-S、DNA)指标的变化;对IRM-2小鼠、C57BL/6 J小鼠进行6.0Gy照射,照后45d,检测小鼠外周血白细胞的变化及绝对值。结果 IRM-2小鼠4.0Gy照射后9 d造血功能三项指标均高于ICR小鼠,CFU-S、DNA差异有统计学意义(P0.001)。6.0Gy照射后45d WBC、RBC及HGB、HCT指标均高于C57BL/6 J小鼠,差异有统计学意义(P0.01)。结论受137Csγ射线大剂量及亚致死剂量照射后,IRM-2小鼠与C57BL/6 J小鼠及ICR小鼠比较,造血系统有较强的恢复功能。
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| 关 键 词： | 小鼠 辐射损伤 造血功能 血细胞分类 |
Comparative Study on Hematopoietic Damage of Mice Caused by High - dose of Gamma - ray Irradiation |
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| Institution: | WU Hong-ying,WANG Yue-Ying,Li De-Guan,et a1.Institute of Radiation Medicine,Chinese Academy of Medical Sciences and Peking Union Medical College,Tianjin Key laboratory of Molecular Nuclear Medicine,Tianjin 300192 China |
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| Abstract: | Objective To study the effect of high-dose of gamma-ray irradiation on hematopoiesis injury and recovery of IRM-2 and C57BL/6J mouse.Methods The experiment was designed to study the effects of radiation（4Gy） on spleen index、CFU-S and DNA damage on the 9th day of IRM-2 and ICR mice and the effects of radiation（6Gy） on WBC change and its absolute value on the 45th days of IRM-2 and C57BL/6J mice.Results The IRM-2 mouse spleen index、CFU-S and DNA were higher than ICR mouse on the 9th days,and there were significant difference in CFU-S and DNA（P0.01）.The IRM-2 mouse WBC、RMC、HGB and HCT were higher than C57BL/6J mouse on the 45th days,and there were significant difference（P0.01）.Conclusion IRM-2 mouse hematopoiesis resumes quicker than C57BL/6J and ICR do after high-dose of gamma-ray irradiation. |
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| Keywords: | Mice Radiation Damage Hematopoiesis WBC |
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