血管内超声评价斑块稳定性及其与血清高敏C反应蛋白和白细胞介素6的关系

目的 应用血管内超声技术探讨不稳定型心绞痛患者不稳定性斑块与血清高敏C反应蛋白和白细胞介素6的关系.方法 38例拟诊为冠心病患者行血管内超声检查,其中8例患者经血管内超声检查未发现冠状动脉有明显狭窄病变为对照组;30例经血管内超声检查发现冠状动脉有明显狭窄病变为冠心病组,其中不稳定型心绞痛18例,稳定型心绞痛组12例.检测所有患者血清高敏C反应蛋白和白细胞介素6水平.结果 38例患者均有不同程度的内膜增厚;8例对照组无动脉粥样硬化斑块;30例冠心病患者有不同类型的动脉粥样硬化斑块.不稳定型心绞痛患者血清高敏C反应蛋白和白细胞介素6水平显著高于稳定型心绞痛组和对照组;不稳定性斑块组高敏C反应蛋白和白细胞介素6水平高于稳定性斑块组.结论 不稳定型心绞痛患者血清高敏C反应蛋白和白细胞介素6水平明显增高,提示高敏C反应蛋白和白细胞介素6水平升高与动脉粥样硬化斑块不稳定性有关.

Relationship Between the Stability of Atherosclerotic Plaque and the Levels of hs-CRP and IL-6 Through Intravascular Ultrasound

Aim To evaluate the relationship between unstable plaques and the levels of high-sensitivity C-reactive protein(hs-CRP)and interleukin-6(IL-6)by intravascular ultrasound(IVUS).Methods 38 patients diagnosed with coronary heart disease by IVUS examination were chosen.Eight patients by IVUS examination were found with no coronary artery stenosis as control group,30 cases by IVUS examination were found with coronary artery stenosis as coronary heart disease group,including 18 cases with unstable angina pectoris(UAP)and 12 cases with stable angina(SAP).Serum hs-CRP and IL-6 levels of all patients were detected.Results 38 patients had varying degrees of intimal thickening.IVUS showed that 30 cases of coronary heart disease patients had different types of atherosclerotic plaque.Serum hs-CRP and IL-6 levels in UAP group were significantly higher than that in SAP group and control group.Serum hs-CRP and IL-6 levels were higher in unstable plaque group than those in stable plaque group.Conclusion Serum hs-CRP and IL-6 was significantly higher in the UAP patients.It prompted that the levels of hs-CRP and IL-6 could reflect the instability degree of atherosclerotic plaque.