耐多药肺结核治疗的近期临床观察

目的分析耐多药肺结核患者采用3CDLfxPtoZ/9DLfxPtoZ方案治疗的近期临床效果。方法 2002年10月至2005年12月收治的100例耐多药肺结核患者,采用3CDLfxPtoZ/9DLfxPtoZ方案治疗,疗程中进行痰结核分枝杆菌检查和肝功能检查,疗程的3、6、9、12个月摄X线胸片。结果 100例完成疗程时痰菌转阴率88.0%,病灶吸收率94.0%,空洞闭合率88.6%。肝功能异常率12.0%,无1例因药物不良反应停药。结论对耐多药肺结核采用方3CDLfxPtoZ/9DLfxPtoZ方案,近期效果满意,药物不良反应轻微,但其确切效果尚需进一步评价。

Clinical observation of treatment in multidrug resistant pulmonary tuberculosis

Objective To evaluate the efficacy of 3CDLfxPtoZ/9DLfxPtoZ regimen for multidrug resistant tuberculosis cases.MethodsOne hundred cases who hospitalized from Oct.2002 to Dec.2005 with multidrug resistant tuberculosis were treated with 3CDLfxPtoZ/9DLfxPtoZ regimen.Sputum smear examination and liver function test were detected for every patient each month,and X-ray chest photographs were taken in the 3^rd,6^th,9^th and 12^th months during the course of treatment.Results All patients completed the treatment.The sputum negative conversion rate was 88%.The focus absorption rate was 94.0%.The cavity closure rate was 88.6%.The rate of abnormal liver function was 12.0%.No patient was suspended with treatment due to adverse reaction of drugs.ConclusionThe regimen of 3CDLfxPtoZ/9DflxPtoZ can provide satisfactory short-term efficacy for multi-drug-resistant tuberculosis and slight adverse effects.But the long-term efficacy needs to be evaluated further.