中国北方汉族人群IL-17F基因His161Arg多态性与心肌梗死的关联

目的 探讨interleukin-17(IL-17F)基因His161Arg单核苷酸多态性与中国北方汉族人群心肌梗死的相关关系.方法 采用聚合酶链反应-限制性片段长度多态性技术对1 068例心肌梗死的患者和985例对照组进行检测,分析IL-17F基因His161Arg单核苷酸多态性的基因型和等位基因分布情况.结果 IL-17F基因His161Arg单核苷酸多态性三种基因型TT型、TC型和CC型在心肌梗死分布频率分别为76.3%、17.9%和5.8%,在对照组分别为75.8%、16.6%和7.6%,两组间的基因型分布皆符合Hardy-Weinberg平衡定律,三种基因型在两组间的分布差异无统计学意义(P>0.05).T等位基因在心肌梗死组和对照组间的分布频率分别为85.3% 和84.2%,差异亦无统计学意义(P=0.33).按性别和年龄等进行亚组分析显示,IL-17F基因His161Arg单核苷酸多态性的基因型和等位基因频率在心肌梗死组和对照组间的差异无统计学意义(P>0.05).结论 IL-17F基因His161Arg单核苷酸多态性与中国北方汉族人群心肌梗死的发病可能无相关关系.

Association of the IL-17F His161Arg Polymorphism and Myocardial Infarctionin Han Population of North China

Aim To assess the possible association between cellular repressor of the interleukin-17(IL-17F)His161Arg polymorphism and myocardial infarction(MI)in a Han Chinese population.Methods We conducted a case-control association study on a cohort of 1 068 unrelated MI patients and 985 age and sex-matched controls to investigate the association between the IL-17F His161Arg polymorphism and MI risk in a Chinese Han population.Results The genotype frequencies of TT,TC and CC in the IL-17F His161Arg polymorphism were 76.3%,17.9% and 5.8% in MI group,75.8%,16.6%,and 7.6% in the controls respectively(P>0.05).The T allele frequency of IL-17F His161Arg polymorphism allele in MI cases and controls were 85.3% and 84.2% respectively(P>=0.33).Further stratification analysis by gender or age and analysis of clinical features in relation to myocardial infarction also yielded negative results(P>0.05).Conclusion This study indicates the IL-17F His161Arg polymorphism is unlikely to be a major contributor to the pathogenesis of MI.